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Titolo:
Gastric mucosal changes induced by long term infection with Helicobacter pylori in Mongolian gerbils: effects of bacteria eradication
Autore:
Keto, Y; Ebata, M; Okabe, S;
Indirizzi:
Kyoto Pharmaceut Univ, Dept Appl Pharmacol, Yamashina, Kyoto 6078414, Japan Kyoto Pharmaceut Univ Yamashina Kyoto Japan 6078414 Kyoto 6078414, Japan
Titolo Testata:
JOURNAL OF PHYSIOLOGY-PARIS
fascicolo: 1-6, volume: 95, anno: 2001,
pagine: 429 - 436
SICI:
0928-4257(200101/12)95:1-6<429:GMCIBL>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-N-NITROSOUREA; INTESTINAL METAPLASIA; INDUCTION; INFLAMMATION; CANCER; ULCER;
Keywords:
Helicobacter pylori; gastric adenocarcinoma; eradication; mongolian gerbils;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Okabe, S Kyoto Pharmaceut Univ, Dept Appl Pharmacol, Yamashina, Kyoto 6078414, Japan Kyoto Pharmaceut Univ Yamashina Kyoto Japan 6078414 78414, Japan
Citazione:
Y. Keto et al., "Gastric mucosal changes induced by long term infection with Helicobacter pylori in Mongolian gerbils: effects of bacteria eradication", J PHYSL-PAR, 95(1-6), 2001, pp. 429-436

Abstract

Helicobacter pylori infection has been reported to induce various mucosal changes, including gastric adenocarcinoma, in Mongolian gerbils 62 weeks after inoculation. Using Mongolian gerbils, this study examined whether or not eradication of the bacteria with drugs at specified times after infectionprevents the development of mucosal changes. After orally inoculating withH. pylori (TN2GF4, vacA- and cagA-positive), the animals were killed 18 months later. Four or 8 months after H. pylori inoculation, eradication was performed by concurrent treatment with omeprazole + clarithromycin. Immediately after treatment ended, in both the 5 and 9 month groups, it was verified that H. pylori was completely eradicated. Autopsy performed 18 months after H. pylori inoculation revealed gastric hyperplastic polyps with erosive lesions and ulcers that were grossly visible in the non-treated control group. In addition, atrophic gastritis, intestinal metaplasia, carcinoids, andadenocarcinomas were histologically observed in the animals. In animals eradicated after 4 months and autopsied after 18 months, however, such mucosal changes were not observed. In contrast, intestinal metaplasia and mucosalatrophy was observed in animals eradicated after 8 months and autopsied after 18 months. It was concluded that early eradication of H. pylori infection with drug therapy can prevent severe gastric mucosal changes, to includeadenocarcinomas, in Mongolian gerbils. (C) 2001 Published by Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 16:29:10