Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Role of leptin in the stomach and the pancreas
Autore:
Konturek, PC; Konturek, SJ; Brzozowski, T; Jaworek, J; Hahn, EG;
Indirizzi:
Jagiellonian Univ, Sch Med, Dept Physiol, PL-31531 Krakow, Poland Jagiellonian Univ Krakow Poland PL-31531 hysiol, PL-31531 Krakow, Poland Univ Erlangen Nurnberg, Dept Med, Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany rg, Dept Med, Erlangen, Germany
Titolo Testata:
JOURNAL OF PHYSIOLOGY-PARIS
fascicolo: 1-6, volume: 95, anno: 2001,
pagine: 345 - 354
SICI:
0928-4257(200101/12)95:1-6<345:ROLITS>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
BODY-WEIGHT; OBESE GENE; SECRETION; RECEPTOR; EXPRESSION; INSULIN; CHOLECYSTOKININ; SYSTEM; BRAIN; RATS;
Keywords:
leptin; stomach; pancreas; gastroprotection; gastric blood flow;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Konturek, SJ Jagiellonian Univ, Sch Med, Dept Physiol, 16 Grzegorzecka St,PL-31531 Krakow, Poland Jagiellonian Univ 16 Grzegorzecka St Krakow Poland PL-31531
Citazione:
P.C. Konturek et al., "Role of leptin in the stomach and the pancreas", J PHYSL-PAR, 95(1-6), 2001, pp. 345-354

Abstract

Leptin, a 16 kDa protein encoded by the ob gene, is known mainly for its role in the regulation of food intake, body composition and energy expenditure through a central feedback mechanism. Initially leptin was considered asan ob gene product of adipocytes but recently the presence of leptin and its receptors have been revealed in other organs including gastric mucosa and the pancreas and found to be released from these organs by cholecystokinin (CCK), gastrin and ordinary feeding. Furthermore, leptin was found to mimick the action of CCK on gastric and pancreatic integrity, while reducing the food intake and to affect gastric and pancreatic secretion. This report emphasizes the role of leptin originating from the gastrointestinal tract acting synergistically with CCK at the hypothalamus level on the mechanism of food intake and locally on the protection of gastric mucosa and the pancreas against noxious agents and to maintain tissue integrity. (C) 2001 Published by Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:43:42