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Titolo:
Therapy effect of antiulcer agents on new chronic cysteamine colon lesion in rat
Autore:
Sikiric, P; Seiwerth, S; Aralica, G; Perovic, D; Staresinic, M; Anic, T; Gjurasin, M; Prkacin, I; Separovic, J; Stancic-Rokotov, D; Lovric-Bencic, M; Mikus, D; Turkovic, B; Rotkvic, I; Mise, S; Rucman, R; Petek, M; Ziger, T; Sebecic, B; Ivasovic, Z; Jagic, V; Komericki, L; Balen, I; Boban-Blagaic, A; Sjekavica, I;
Indirizzi:
Univ Zagreb, Fac Med, Dept Pharmacol, Zagreb, Croatia Univ Zagreb ZagrebCroatia eb, Fac Med, Dept Pharmacol, Zagreb, Croatia Univ Zagreb, Fac Med, Dept Pathol, Zagreb, Croatia Univ Zagreb Zagreb Croatia agreb, Fac Med, Dept Pathol, Zagreb, Croatia
Titolo Testata:
JOURNAL OF PHYSIOLOGY-PARIS
fascicolo: 1-6, volume: 95, anno: 2001,
pagine: 283 - 288
SICI:
0928-4257(200101/12)95:1-6<283:TEOAAO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
PENTADECAPEPTIDE BPC-157; EXPERIMENTAL-MODEL; DOPAMINE AGONISTS; DUODENAL ULCERS; INDUCED COLITIS; INDOMETHACIN; STOMACH; STRESS; ANTAGONISTS; DISEASE;
Keywords:
cysteamine chronic colon lesions; recidive; pentadecapeptide BPC 157; gastroduodenal antiulcer agents; remedies for inflammatory bowel disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Sikiric, P Univ Zagreb, Fac Med, Dept Pharmacol, Salata 11,POB 916, Zagreb, Croatia Univ Zagreb Salata 11,POB 916 Zagreb Croatia Zagreb, Croatia
Citazione:
P. Sikiric et al., "Therapy effect of antiulcer agents on new chronic cysteamine colon lesion in rat", J PHYSL-PAR, 95(1-6), 2001, pp. 283-288

Abstract

After demonstration that cysteamine induced duodenal lesions in gastrectomized rats, while a number of antiulcer drugs mitigated these lesions, it was shown that one single intrarectal (i.r.) cysteamine application produced severe colon lesions in acute studies in rats. Thus, the further focus was on the protracted effect of cysteamine challenge (400 mg/kg b.w. i.r.) and therapy influence in chronic experiments in female rats. Regularly, cysteamine colon lesions were markedly mitigated by ranitidine (10), omeprazole (10), atropine (10), methylprednisolone (1), sulphasalazine (50; mg/kg), pentadecapeptide BPC 157 (PL-10, PLD-116, 10 mug or 10 ng/kg). Specifically, after 1 or 3 months following initial challenge (cysteamine 400 mg/kg i.r.) in female rat, the therapy [BPC 157 (PL-10, PLD-116 (10.0 mug or 10.0 ng/kg;i.g., i.p., i.r.), ranitidine, omeprazole, atropine, methylprednisolone, sulphasalazine (i.p.)] reversed the protracted cysteamine colon injury: the 1 week-regimen (once daily application) started after 1 month post-cysteamine, as well as the 2 weeks-regimen (once daily application), which started after 3 months. The effect on recidive lesion was also tested. These cysteamine lesions may reappear after stopping therapy (after stopping therapy for 3 weeks at the end of 2-weeks regimen started in 3 months-cysteamine female rats) in sulphasalazine group, while this reappearance is markedly antagonized in pentadecapeptide BPC 157 (PL-10, PLD-116)-rats (cysteamine-colon lesion still substantially low). (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:25:18