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Titolo:
Involvement of the opioid system in the central antisecretory action of alpha-2 adrenoceptor agonists in rat
Autore:
Mullner, K; Gyires, K; Furst, S;
Indirizzi:
Semmelweis Univ Med, Fac Med, Dept Pharmacol & Pharmacotherapy, H-1445 Budapest, Hungary Semmelweis Univ Med Budapest Hungary H-1445 py, H-1445 Budapest, Hungary
Titolo Testata:
JOURNAL OF PHYSIOLOGY-PARIS
fascicolo: 1-6, volume: 95, anno: 2001,
pagine: 209 - 214
SICI:
0928-4257(200101/12)95:1-6<209:IOTOSI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTRIC-ACID SECRETION; BETA-ENDORPHIN; AUTORADIOGRAPHIC LOCALIZATION; CLONIDINE; RECEPTORS; BRAIN; SUBTYPES; GASTROPROTECTION; MECHANISMS; STRESS;
Keywords:
gastric acid secretion; clonidine; oxymetazoline; yohimbine; naloxone; naltrindole; icv;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Mullner, K Semmelweis Univ Med, Fac Med, Dept Pharmacol & Pharmacotherapy,POB 370, H-1445 Budapest, Hungary Semmelweis Univ Med POB 370 Budapest Hungary H-1445 t, Hungary
Citazione:
K. Mullner et al., "Involvement of the opioid system in the central antisecretory action of alpha-2 adrenoceptor agonists in rat", J PHYSL-PAR, 95(1-6), 2001, pp. 209-214

Abstract

The aim of the present study was to analyse the role of the central alpha-2 adrenoceptors in the regulation of gastric acid secretion in pylorus ligated rats. It was found that the intracerebroventricularly (icv.) injected presynaptic alpha-2 adrenoceptor agonist clonidine and the alpha-2A adrenoceptor subtype selective stimulant oxymetazoline exerted a dose dependent inhibition on gastric acid secretion. The antisecretory ED50 values for clonidine and oxymetazoline were 20 and 7.5 nmol/rat icv., respectively. The antisecretory effect of these compounds was antagonised by the presynaptic adrenoceptor antagonist yohimbine (50 nmol/rat icv.) indicating that the actionis mediated through central presynaptic alpha-2 adrenoceptors. Moreover, naloxone (50 nmol/rat icv.)non-selective opioid antagonist-and naltrindole (0.5 nmol/rat icv.)-delta-opioid receptor selective antagonist-also decreased the antisecretory effect of clonidine and oxymetazoline suggesting that the endogenous opioid system is likely to be involved in the central antisecretory action of alpha-2 adrenoceptor stimulants. (C) 2001 Elsevier ScienceLtd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 06:33:43