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Titolo:
Capsaicin-sensitive afferents and their role in gastroprotection: an update
Autore:
Szolcsanyi, J; Bartho, L;
Indirizzi:
Univ Pecs, Fac Med, Dept Pharmacol & Pharmacotherapy, H-7624 Pecs, HungaryUniv Pecs Pecs Hungary H-7624 ol & Pharmacotherapy, H-7624 Pecs, Hungary
Titolo Testata:
JOURNAL OF PHYSIOLOGY-PARIS
fascicolo: 1-6, volume: 95, anno: 2001,
pagine: 181 - 188
SICI:
0928-4257(200101/12)95:1-6<181:CAATRI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; HEALTHY-HUMAN SUBJECTS; ROOT GANGLION NEURONS; MUCOSAL BLOOD-FLOW; SENSORY NEURONS; GUINEA-PIG; VANILLOID RECEPTOR-1; VAGAL AFFERENTS; RAT STOMACH; FIBERS;
Keywords:
afferents; gastroprotection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Szolcsanyi, J Univ Pecs, Fac Med, Dept Pharmacol & Pharmacotherapy, SzietiU12, H-7624 Pecs, Hungary Univ Pecs Szieti U12 Pecs Hungary H-7624 7624 Pecs, Hungary
Citazione:
J. Szolcsanyi e L. Bartho, "Capsaicin-sensitive afferents and their role in gastroprotection: an update", J PHYSL-PAR, 95(1-6), 2001, pp. 181-188

Abstract

The pivotal role of capsaicin-sensitive peptidergic sensory fibers in the maintenance of gastric mucosal integrity against injurious interventions was suggested by the authors 20 years ago. Since then substantial evidence has accumulated for the local sensory-efferent function of the released CGRP,tachykinins and NO in this gastroprotective mechanism. This overview outlines some recent achievements which shed light on new aspects and further horizons in this field. (1) Cloning the capsaicin VR-1 receptor (an ion channel-coupled receptor) and raising the VR-1 knockout mice provided a definitemolecular background for the existence of capsaicin-sensitive afferents with both sensory and mediator releasing functions in the stomach. This cation channel is also sensitive to hydrogen ions. (2) VR-1 agonists (capsaicin,resiniferatoxin, piperine) protect against gastric ulcer of the rat parallel with their sensory stimulating potencies. (3) Antidromic stimulation of capsaicin-sensitive vagal and somatic afferents results in the release of CGRP, tachykinins, NO and somatostatin. Somatostatin with gastroprotective effect is released from D cells and sensory nerve endings. (4) The recent theory for the existence of spinal afferents without sensory function [P. Holzer, C.A. Maggi, Dissociation of dorsal root ganglion neurons into afferentand efferent-like neurons, Neuroscience 86 (1998) 389-398] is discussed. Data proposed to support this theory are interpreted here on the basis of a dual sensory-efferent function of VR-1 positive afferents, characterized bya frequency optimum of discharges for release vasodilatory neuropeptides below the nociceptive threshold. (5) Recent data on the effect of capsaicin in healthy human stomach are summarized. These results indicate that the gastroprotective effect of capsaicin in the human stomach involves additionalmechanisms to those already revealed in the rat.,(C) 2001 Published by Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:47:11