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Titolo:
Bicarbonate stimulatory action of nizatidine, a histamine H-2-receptor antagonist, in rat duodenums
Autore:
Mimaki, H; Kawauchi, S; Kagawa, S; Ueki, S; Takeuchi, K;
Indirizzi:
Kyoto Pharmaceut Univ, Dept Pharmacol & Expt Therapeut, Kyoto 6078414, Japan Kyoto Pharmaceut Univ Kyoto Japan 6078414 herapeut, Kyoto 6078414, Japan
Titolo Testata:
JOURNAL OF PHYSIOLOGY-PARIS
fascicolo: 1-6, volume: 95, anno: 2001,
pagine: 165 - 171
SICI:
0928-4257(200101/12)95:1-6<165:BSAONA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTRIC-ACID SECRETION; RANITIDINE; INHIBITION; MOTILITY; ULCER;
Keywords:
duodenal HCO3- secretion; nizatidine; histamine H-2-receptor antagonist; anti-AChE activity; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Takeuchi, K Kyoto Pharmaceut Univ, Dept Pharmacol & Expt Therapeut, Kyoto 6078414, Japan Kyoto Pharmaceut Univ Kyoto Japan 6078414 oto 6078414, Japan
Citazione:
H. Mimaki et al., "Bicarbonate stimulatory action of nizatidine, a histamine H-2-receptor antagonist, in rat duodenums", J PHYSL-PAR, 95(1-6), 2001, pp. 165-171

Abstract

Nizatidine, a histamine H-2-antagonist, is known to inhibit acetylcholinesterase (AChE) activity and is used clinically as a gastroprokinetic agent as well as the anti-ulcer agent. We examined whether or not nizatidine stimulates duodenal HCO3- secretion in rats through vagal-cholinergic mechanismsby inhibiting AChE activity. Under pentobarbital anesthesia, a proximal duodenal loop was perfused with saline, and the HCO3- secretion was measured at pH 7.0 using a pH-stat method and by adding 10 mM HCl. Nizatidine, neostigmine, carbachol, famotidine or ranitidine was administered i.v. as a single injection. Intravenous administration of nizatidine (3-30 mg/kg) dose-dependently increased the HCO3- secretion, and the effect at 10 mg/kg was equivalent to that obtained by carbachol at 0.01 mg/kg. The HCO3- stimulatory action of nizatidine was observed at the doses that inhibited the histamine-induced acid secretion and enhanced gastric motility. This effect was mimicked by neostigmine (0.03 mg/kg) and significantly attenuated by bilateral vagotomy and pretreatment with atropine but not indomethacin. The IC50 of nizatidine for AChE of rat erythrocytes was 1.4 x 10(-6) M, about 12 times higher than that of neostigmine. Ranitidine showed the anti-AchE activity and increased duodenal HCO3- secretion, similar to nizatidine, whereas famotidine had any influence on neither AChE activity nor the HCO3- secretion. Onthe other hand, duodenal damage induced by acid perfusion (100 mM HCl for 4 h) in the presence of indomethacin was significantly prevented by nizatidine and neostigmine, at the doses that increased the HCO3- secretion. Theseresults suggest that nizatidine increases HCO secretion in the rat duodenum, mediated by vagal-cholinergic mechanism, the action being associated with the anti-AChE activity of this agent. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 17:52:29