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Titolo:
The Fc gamma receptor genotype as a severity factor for chronic periodontitis in Japanese patients
Autore:
Kobayashi, T; Yamamoto, K; Sugita, N; van der Pol, WL; Yasuda, K; Kaneko, S; van de Winkel, JGJ; Yoshie, H;
Indirizzi:
Niigata Univ, Grad Sch Med & Dent Sci, Dept Oral Biol Sci, Div Periodontol, Niigata, Japan Niigata Univ Niigata Japan al Biol Sci, Div Periodontol, Niigata, Japan Univ Utrecht, Med Ctr, Immunotherapy Lab, Dept Immunol, Utrecht, Netherlands Univ Utrecht Utrecht Netherlands ab, Dept Immunol, Utrecht, Netherlands Univ Utrecht, Med Ctr, Genmab, Utrecht, Netherlands Univ Utrecht UtrechtNetherlands Med Ctr, Genmab, Utrecht, Netherlands
Titolo Testata:
JOURNAL OF PERIODONTOLOGY
fascicolo: 10, volume: 72, anno: 2001,
pagine: 1324 - 1331
SICI:
0022-3492(200110)72:10<1324:TFGRGA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
GINGIVAL CREVICULAR FLUID; ADULT PERIODONTITIS; IGG SUBCLASSES; RISK-FACTORS; TOOTH LOSS; RIIA CD32; LONG-TERM; DISEASE; POLYMORPHISM; TISSUE;
Keywords:
periodontitis; polymorphism; receptors, polymeric immunoglobulins; IgG; Japanese;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Kobayashi, T Niigata Univ, Grad Sch Med & Dent Sci, Dept Oral Biol Sci, Div Periodontol, Niigata, Japan Niigata Univ Niigata Japan Div Periodontol, Niigata, Japan
Citazione:
T. Kobayashi et al., "The Fc gamma receptor genotype as a severity factor for chronic periodontitis in Japanese patients", J PERIODONT, 72(10), 2001, pp. 1324-1331

Abstract

Background: Functional polymorphisms of immunoglobulin G (IgG) Fc receptors (Fc gammaR) have been shown to be associated with generalized aggressive periodontitis (GAgP) or recurrence of chronic periodontitis (CP) in Japanese patients. The purpose of this study was to evaluate whether Fc gammaR polymorphisms are also associated with severity of CP. Methods: Fifty Japanese non-smoking patients with severe CP and 39 Japanese non-smoking patients with moderate CP were identified according to established clinical criteria, including measurements of probing depth (PD), clinical attachment level (CAL), and alveolar bone loss (BL). Fc gammaR genotypes for 3 bi-allelic polymorphisms (Fc gamma RIIa-R/H131, Fc gamma RIIIa-158V/F, Fc gamma RIIIb-NA1/NA2) were determined in these CP patients and 64 race-matched, non-smoking healthy controls by means of allele-specific polymerase chain reactions. Results: There was a significant over-representation of Fc gamma RIIIa-158V allele in severe CP patients compared to moderate CP patients (odds ratio2.03, 95% confidence interval [CI] 1.03-4.01, chi (2) = 4.86, P = 0.028). In addition, we found a strong association between CP severity and Fc gammaR composite genotype comprising Fc gamma RIIIa-158V plus Fc gamma RIIIb-NA2(severe CP versus moderate CP: odds ratio 4.69, 95% Cl 1.52-15.10, chi (2)= 9.35, P = 0.002; severe CP versus healthy controls: odds ratio 4.10, 95%Cl 1.62-10.59, chi (2) = 11.13, P = 0.0009). Moreover, CP patients positive for the composite genotype exhibited more severe signs of periodontitis than composite genotype-negative individuals (positive versus negative; meanPD: 3.8 mm versus 3.2 mm, P = 0.005; mean CAL: 4.5 mm versus 3.7 mm, P = 0.005; mean % BL: 37.6% versus 29.9%, P = 0.008). Conclusion: Our results document the Fc gamma RIIIa-158V allele and possibly Fc gamma RIIIb-NA2 to be associated with severity of CP in Japanese patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/10/20 alle ore 03:40:06