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Titolo:
Novel capsaicin (VR1) and purinergic (P2X(3)) receptors in Hirschsprung's intestine
Autore:
Facer, P; Knowles, CH; Tam, PKH; Ford, AP; Dyer, N; Baecker, PA; Anand, P;
Indirizzi:
Univ Hong Kong, Queen Mary Hosp, Med Ctr, Dept Surg,Div Paediat Surg, HongKong, Hong Kong, Peoples R China Univ Hong Kong Hong Kong Hong Kong Peoples R China Kong, Peoples R China Univ London Imperial Coll Sci Technol & Med, Sch Med, Peripheral Neuropathy Unit, London, England Univ London Imperial Coll Sci Technol & Med London England don, England Roche Biosci, Palo Alto, CA USA Roche Biosci Palo Alto CA USARoche Biosci, Palo Alto, CA USA St Bartholomews & Royal London Sch Med & Dent, Acad Dept Surg, London, England St Bartholomews & Royal London Sch Med & Dent London England n, England Queen Mary Hosp, Div Paediat Surg, Hong Kong, Hong Kong, Peoples R China Queen Mary Hosp Hong Kong Hong Kong Peoples R China ong, Peoples R China
Titolo Testata:
JOURNAL OF PEDIATRIC SURGERY
fascicolo: 11, volume: 36, anno: 2001,
pagine: 1679 - 1684
SICI:
0022-3468(200111)36:11<1679:NC(AP(>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSORY NEURONS; DISEASE; IMMUNOHISTOCHEMISTRY; FIBERS;
Keywords:
vanilloid; vanilloid receptor 1; Hirschsprung's disease; P2X(3); ATP-gated ion channel; capsaicin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Anand, P Univ Hong Kong, Queen Mary Hosp, Med Ctr, Dept Surg,Div Paediat Surg, HongKong, Hong Kong, Peoples R China Univ Hong Kong Hong Kong Hong Kong Peoples R China ples R China
Citazione:
P. Facer et al., "Novel capsaicin (VR1) and purinergic (P2X(3)) receptors in Hirschsprung's intestine", J PED SURG, 36(11), 2001, pp. 1679-1684

Abstract

Background/Purpose: Studies of Hirschsprung's disease (HSCR) have shown that hypertrophic nerves in aganglionic bowel are mainly of extrinsic origin and may contain sensory elements. Recent advances have shown a specific capsaicin receptor VR1 (vanilloid receptor-1), and an ATP-gated ion channel P2X(3), which are expressed by sensory neurons. Methods: This study investigated, for the first time, the distribution of VR1- and P2X(3)-immunoreactivity in normal adult, infant, and HSCR large intestine, using specific antibodies for immunohistochemistry. Results: VR1-immunoreactive fibers and nerve fascicles, but not somata, were detected in all regions of the bowel in controls with few weakly immunostained fibers in the mucosa/ lamina propria. Hypertrophic nerve bundles in hypoganglionic and aganglionic bowel showed intense VR1-immunoreactivity, whereas normoganglionic regions of HSCR were similar to controls. P2X(3)-immunoreactive neuronal cell bodies, in some instances with long axonal processes, were detected in the myenteric and submucous plexuses in control infant, adult, and ganglionic HSCR samples. Aganglionic samples showed weak P2X(3)-immunoreactivity in hypertrophic nerve fasciculi in the submucous and myenteric plexuses. Conclusions: The presence of VR1- and P2X(3)-immunoreactivities in aganglionic HSCR bowel indicates that sensory nerves may form a significant proportion of its hypertrophic innervation. The functional significance of P2X(3)and VR1 receptors in enteric nerves deserves further investigation. J Pediatr Surg 36:1679-1684. Copyright (C) 2001 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 09:21:23