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Titolo:
Plasma endothelin-1 level as a marker reflecting the severity of portal hypertension in biliary atresia
Autore:
Hasegawa, T; Kimura, T; Sasaki, T; Okada, A;
Indirizzi:
Osaka Univ, Sch Med, Dept Pediat Surg, Osaka 5650871, Japan Osaka Univ Osaka Japan 5650871 d, Dept Pediat Surg, Osaka 5650871, Japan
Titolo Testata:
JOURNAL OF PEDIATRIC SURGERY
fascicolo: 11, volume: 36, anno: 2001,
pagine: 1609 - 1612
SICI:
0022-3468(200111)36:11<1609:PELAAM>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLINICAL-SIGNIFICANCE; CIRRHOSIS; VARICES; EXPERIENCE; RELEASE; SHUNT;
Keywords:
biliary atresia; portal hypertension; endothelin; gastroesophageal varices; hypersplenism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Hasegawa, T Osaka Univ, Sch Med, Dept Pediat Surg, 2-2 Yamadaoka, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Osaka Japan 5650871 a 5650871, Japan
Citazione:
T. Hasegawa et al., "Plasma endothelin-1 level as a marker reflecting the severity of portal hypertension in biliary atresia", J PED SURG, 36(11), 2001, pp. 1609-1612

Abstract

Background/Purpose. The aim of this study was to examine if the plasma endothelin-1 (ET-1), a potent vasoconstrictor, level may reflect the severity of portal hypertension associated with liver cirrhosis in biliary atresia (BA). Methods: Forty-eight postoperative BA patients aged 6 months to 20 years were studied. Plasma ET-1 was measured by a sandwich method of enzyme immunoassay. ET-1 was compared with Child's score and laboratory data. ET-1 levels were compared among groups of patients with various degrees of histologicfibrosis and portal hypertension. Results: Plasma ET-1 was 5.3 +/- 3.5 pg/mL in BA, higher than in controls (3.1 +/- 0.8, n = 27; P <.05). ET-1 correlated with Child's score, serum total bilirubin, direct bilirubin, aspartate aminotransferase, albumin, prothrombin time, hepaplastin test, fibrinogen, cholinesterase, total cholesterol, Fischer's molar ratio, prealubumin, and hyaluronic acid, respectively (P<.05). ET-1 also correlated with the severity of histologic fibrosis, gastroesophageal varices, the presence of splenomegaly, ascites, venous dilatation on the abdominal wall, or pulmonary vascular abnormalities. In 4 patients undergoing liver transplantation (LTx), ET-1 after LTx was lower than that before LTx (P <.05). Conclusion: Plasma ET-1 level may be a useful index reflecting the severity of cirrhosis and portal hypertension in BA. J Pediatr Surg 36:1609-1612. Copyright (C) 2001 by W.B Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 09:25:58