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Titolo:
Localization of human frontal eye fields: anatomical and functional findings of functional magnetic resonance imaging and intracerebral electrical stimulation
Autore:
Lobel, E; Kahane, P; Leonards, U; Grosbras, MH; Lehericy, S; Le Bihan, D; Berthoz, A;
Indirizzi:
Coll France, Lab Physiol Percept & Act, F-75005 Paris, France Coll FranceParis France F-75005 ol Percept & Act, F-75005 Paris, France CEA, Serv Hosp Frederic Joliot, Orsay, France CEA Orsay FranceCEA, Serv Hosp Frederic Joliot, Orsay, France CHU Grenoble, INSERM, F-38043 Grenoble, France CHU Grenoble Grenoble France F-38043 e, INSERM, F-38043 Grenoble, France
Titolo Testata:
JOURNAL OF NEUROSURGERY
fascicolo: 5, volume: 95, anno: 2001,
pagine: 804 - 815
SICI:
0022-3085(200111)95:5<804:LOHFEF>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; SPATIAL WORKING-MEMORY; MOTOR HAND AREA; HUMAN BRAIN; CEREBRAL-CORTEX; CORTICAL CONTROL; MOVEMENTS; SACCADES; ACTIVATION; EPILEPSY;
Keywords:
frontal eye field; functional magnetic resonance imaging; electrical stimulation; saccadic eye movement;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Berthoz, A Coll France, Lab Physiol Percept & Act, 13 Pl Marcelin Berthelot, F-75005 Paris, France Coll France 13 Pl Marcelin Berthelot Paris FranceF-75005 ance
Citazione:
E. Lobel et al., "Localization of human frontal eye fields: anatomical and functional findings of functional magnetic resonance imaging and intracerebral electrical stimulation", J NEUROSURG, 95(5), 2001, pp. 804-815

Abstract

Object. The goal of this study was to investigate the anatomical localization and functional role of human frontal eye fields (FEFs) by comparing findings from two independently conducted studies. Methods. In the first study, 3-tesla functional magnetic resonance (fMR) imaging was performed in 14 healthy volunteers divided into two groups: the first group executed self-paced voluntary saccades in complete darkness andthe second group repeated newly learned or familiar sequences of saccades. In the second study, intracerebral electrical stimulation (IES) was performed in 38 patients with epilepsy prior to surgery, and frontal regions where stimulation induced versive eye movements were identified. These studies showed that two distinct oculomotor areas (OMAs) could be individualized inthe region classically corresponding to the FEFs. One OMA was consistentlylocated at the intersection of the superior frontal sulcus with the fundusof the superior portion of the precentral sulcus, and was the OMA in whichsaccadic eve movements could be the most easily elicited by electrical stimulation. The second OMA was located more laterally, close to the surface of the precentral gyrus. The fMR imaging study and the DES study demonstrated anatomical ana stereotactic agreement in the identification of these cortical areas. Conclusions. These findings indicate that infracentimetric localization ofcortical areas can be achieved by measuring the vascular signal with the aid of 3-tesla fMR imaging and that neuroimaging and electrophysiological recording can be used together to obtain a better understanding of the human cortical functional anatomy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:17:57