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Titolo:
The influence of hemodynamic stress factors on intracranial aneurysm formation
Autore:
Turner, CL; Tebbs, S; Smielewski, P; Kirkpatrick, PJ;
Indirizzi:
Univ Cambridge, Addenbrookes Hosp, Dept Neurosurg, Cambridge CB2 2QQ, England Univ Cambridge Cambridge England CB2 2QQ urg, Cambridge CB2 2QQ, England
Titolo Testata:
JOURNAL OF NEUROSURGERY
fascicolo: 5, volume: 95, anno: 2001,
pagine: 764 - 770
SICI:
0022-3085(200111)95:5<764:TIOHSF>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PULSE-WAVE VELOCITY; SUBARACHNOID HEMORRHAGE; AUGMENTATION INDEX; CARDIOVASCULAR MORTALITY; ARTERIAL STIFFNESS; AORTIC PRESSURE; BLOOD-PRESSURE; HEAD-INJURY; CIRCULATION; VALIDATION;
Keywords:
augmentation index; intracranial aneurysm; subarachnoid hemorrhage;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Kirkpatrick, PJ Univ Cambridge, Addenbrookes Hosp, Dept Neurosurg, Hills Rd,Block A,Level 4, Cambridge CB2 2QQ, England Univ Cambridge Hills Rd,BlockA,Level 4 Cambridge England CB2 2QQ
Citazione:
C.L. Turner et al., "The influence of hemodynamic stress factors on intracranial aneurysm formation", J NEUROSURG, 95(5), 2001, pp. 764-770

Abstract

Object. Applanation tonometry is a noninvasive method of assessing both peripheral and central arterial blood pressure (BP) profiles. In this study the authors examine whether there are differences in these profiles in patients with intracranial aneurysms when compared with age-matched controls. Methods. Carotid artery (CA) and derived aortic BP waveforms were obtainedusing a pulse wave analysis system. The ratio of the pressure wave amplitude above the systolic shoulder to the total systolic BP (augmentation index[AI]) was recorded. One hundred seventy-three patients with intracranial aneurysms (23 unruptured lesions) and 173 healthy control volunteers were examined. For the patients with aneurysms the right and left CA Als (mean +/- standard deviation)were 125.6 +/- 23.1% and 128.3 +/- 22.1%, respectively. Corresponding values for the control group were 118.4 +/- 22.6% and 119.4 +/- 21.8%. The calculated Al for the ascending aorta was 29.8 +/- 10.5% and 25.6 +/- 12.2% forpatients with aneurysms and control volunteers, respectively. Significant asymmetry in CA Al was seen in patients with aneurysms, the left being greater (p = 0.002). No significant differences were seen in mean BP (108 +/- 14 mm Hg in patients with aneurysms compared with 106 +/- 16 mm Hg in controls; p = 0.2). Multivariate analysis excluded the influence of BP and other potential confounding vascular risk factors for increased ALConclusions. Significant differences in AT, both in magnitude and symmetry, were identified in patients with intracranial aneurysms when compared with matched controls.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:00:36