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Titolo:
Nitric oxide synthase/nicotinamide adenine dinucleotide phosphate-diaphorase in the brainstem trigeminal nuclei after transection of the masseteric nerve in rats
Autore:
Varathan, V; Shigenaga, Y; Takemura, M;
Indirizzi:
Osaka Univ, Grad Sch Dent, Dept Oral Anat & Neurobiol, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 urobiol, Suita, Osaka 5650871, Japan Osaka Univ, Grad Sch Dent, Dept Oral Radiol, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 Radiol, Suita, Osaka 5650871, Japan
Titolo Testata:
JOURNAL OF NEUROSCIENCE RESEARCH
fascicolo: 3, volume: 66, anno: 2001,
pagine: 428 - 438
SICI:
0360-4012(20011101)66:3<428:NOSADP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOS PROTEIN EXPRESSION; NADPH-DIAPHORASE; MOTOR-NEURONS; NEUROTROPHIC FACTOR; SPINAL-CORD; SYNTHASE IMMUNOREACTIVITY; FACIAL-NERVE; AXOTOMY; INFLAMMATION; DEATH;
Keywords:
nerve injury; nitric oxide; histochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Takemura, M Osaka Univ, Grad Sch Dent, Dept Oral Anat & Neurobiol, 1-8 Yamadaoka, Suita, Osaka 5650871, Japan Osaka Univ 1-8 Yamadaoka Suita Osaka Japan 5650871 0871, Japan
Citazione:
V. Varathan et al., "Nitric oxide synthase/nicotinamide adenine dinucleotide phosphate-diaphorase in the brainstem trigeminal nuclei after transection of the masseteric nerve in rats", J NEUROSC R, 66(3), 2001, pp. 428-438

Abstract

In this study, the responses of nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) and neuronal nitric oxide synthase (nNOS) activitieswere quantitatively analyzed at different times in both ipsilateral and contralateral sides of trigeminal nuclei, after unilateral trigeminal muscle nerve transection, in Sprague Dawley rats. In the control animals, both NADPH-d- and nNOS-positive neurons were constitutively distributed in the rostrolateral solitary tract nucleus, dorsomedial part of trigeminal nucleus oralis (Vo/Sn), and superficial layers (Vcl/ll) of the trigeminal nucleus caudalis (Vc). NADPH-d-positive neurons appeared in the trigeminal mesencephalic nucleus ipsilaterally at 5 days (mean SEM: 30.5 +/- 5.6) and were maintained until 8 weeks (33 +/- 10.6) after the denervation. In the trigeminal motor nucleus, NADPH-d-positive neurons appeared transiently and bilaterally, peaking at 1 week (663.5 +/- 156.2, ipsilateral side; 687.5 +/- 118.6, contralateral side) after unilateral denervation of the masseteric nerve. In both Vo/Sn and Vc, the number of NADPH-d-positive neurons in the control animals showed a decrease at 3 days but significantly increased from 5 days to 1 week and gradually fell to the control values by 8 weeks after the denervation. There were no significant differences observed between the two sides in either Vo/Sn or Vc. nNOS-positive neurons were similarly distributed and the numbers of labeled neurons were similar to those of NADPH-d-positive neurons after the denervation, although the changes were delayed by approximately 1 week. In conclusion, after unilateral nerve transection, the peak NADPH-d activity occurs 1 week prior to nNOS activity. (C) 2001 Wiley-Liss, Inc.

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Documento generato il 07/04/20 alle ore 22:47:19