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Titolo:
Brain remodeling due to neuronal and astrocytic proliferation after controlled cortical injury in mice
Autore:
Kernie, SG; Erwin, TM; Parada, LF;
Indirizzi:
Univ Texas, SW Med Ctr, Ctr Basic Res Nerve Growth & Regenerat, Dallas, TX75390 USA Univ Texas Dallas TX USA 75390 ve Growth & Regenerat, Dallas, TX75390 USA Univ Texas, SW Med Ctr, Kent Waldrep Fdn Ctr Basic Res Nerve Growth & Reg,Dept Pediat, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 th & Reg,Dept Pediat, Dallas, TX 75390 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE RESEARCH
fascicolo: 3, volume: 66, anno: 2001,
pagine: 317 - 326
SICI:
0360-4012(20011101)66:3<317:BRDTNA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; ADULT-RAT HIPPOCAMPUS; NEURAL STEM-CELL; SPINAL-CORD; REACTIVE ASTROCYTES; NEUROTROPHIC FACTOR; NEUROGENESIS; RECOVERY; CORTEX; CNS;
Keywords:
stem cell; regeneration; astrogliosis; traumatic brain injury; neurogenesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Kernie, SG Univ Texas, SW Med Ctr, Ctr Basic Res Nerve Growth & Regenerat,6000 HarryHines Blvd, Dallas, TX 75390 USA Univ Texas 6000 Harry Hines Blvd Dallas TX USA 75390 75390 USA
Citazione:
S.G. Kernie et al., "Brain remodeling due to neuronal and astrocytic proliferation after controlled cortical injury in mice", J NEUROSC R, 66(3), 2001, pp. 317-326

Abstract

The persistence of neural stem cells into adulthood has been an area of intense investigation in recent years. There is limited knowledge about how an acquired brain injury might affect the ability of neural precursor cells to proliferate and repopulate injured areas. In the present study we utilize a controlled cortical impact model of traumatic brain injury in adult mice and subsequent BrdU labeling to demonstrate that there is significant proliferation of neural precursors in response to traumatic brain injury in areas both proximal and distal to the injury site. The fate of the proximal proliferation is almost exclusively astrocytic at 60-days post injury and demonstrates that newly generated cells make up much of the astrogilotic scar. Moreover, in areas more distal from the injury site, neurogenesis occurs within the granular layer of the dentate gyrus at a level more than five-fold greater than in controls. These data demonstrate that neural proliferation plays key roles in the remodeling that occurs after traumatic brain injury and suggests a mechanism as to how functional recovery after traumatic brain injuries continues to occur long after the injury itself. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 21:34:44