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Titolo:
Intracerebroventricular adrenomedullin stimulates the hypothalamic-pituitary-adrenal axis, the sympathetic nervous system and production of hypothalamic nitric oxide
Autore:
Shan, J; Krukoff, TL;
Indirizzi:
Univ Alberta, Fac Med & Dent, Dept Cell Biol, Edmonton, AB T6G 2H7, CanadaUniv Alberta Edmonton AB Canada T6G 2H7 iol, Edmonton, AB T6G 2H7, Canada
Titolo Testata:
JOURNAL OF NEUROENDOCRINOLOGY
fascicolo: 11, volume: 13, anno: 2001,
pagine: 975 - 984
SICI:
0953-8194(200111)13:11<975:IASTH>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-FOS EXPRESSION; CORTICOTROPIN-RELEASING FACTOR; PARAVENTRICULAR NUCLEUS; SUPRAOPTIC NUCLEI; BRAIN-STEM; RAT-BRAIN; HYPOTENSIVE PEPTIDE; CONSCIOUS SHEEP; IMMUNE STRESS; NEURONS;
Keywords:
paraventricular nucleus; locus coeruleus; c-fos; tyrosine hydroxylase; ACTH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Krukoff, TL Univ Alberta, Fac Med & Dent, Dept Cell Biol, Edmonton, AB T6G2H7, Canada Univ Alberta Edmonton AB Canada T6G 2H7 n, AB T6G 2H7, Canada
Citazione:
J. Shan e T.L. Krukoff, "Intracerebroventricular adrenomedullin stimulates the hypothalamic-pituitary-adrenal axis, the sympathetic nervous system and production of hypothalamic nitric oxide", J NEUROENDO, 13(11), 2001, pp. 975-984

Abstract

We tested the hypothesis that central adrenomedullin stimulates activity of the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic output fromthe brain, and we assessed the effects of central adrenomedullin on the nitric oxide (NO) system in the brain. In conscious rats, intracerebroventricular (i.c.v.) injections of adrenomedullin (2 nmol/kg) increased arterial pressure and heart rate, with return to baseline values within 20 min and 65min of injections, respectively. Adrenomedullin injections augmented expression of tyrosine hydroxylase mRNA in the locus coeruleus after 4 h. Plasmaconcentrations of adrenocorticotropic hormone, measured with radioimmunoassay, were also increased by adrenomedullin. i.c.v. Adrenomedullin stimulated Fos expression in neurones within autonomic centres including the paraventricular nucleus (PVN) of the hypothalamus, arcuate nucleus, locus coeruleus, nucleus of the tractus solitarius and area postrema. In the PVN, large proportions of corticotropin releasing factor- and NO-producing neurones were activated (Fos positive). NO production, measured with nitrate/nitrite assays, was elevated in the hypothalamus, but not brainstem, of adrenomedullin-treated rats compared to controls. We conclude that centrally administered adrenomedullin stimulates activity of the HPA axis, the sympathetic nervous system, and the hypothalamic NO system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:06:37