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Titolo:
Two kinds of mitogen-activated protein kinase phosphatases, MKP-1 and MKP-3, are differentially activated by acute and chronic methamphetamine treatment in the rat brain
Autore:
Takaki, M; Ujike, H; Kodama, M; Takehisa, Y; Nakata, K; Kuroda, S;
Indirizzi:
Okayama Univ, Grad Sch Med & Dent, Dept Neuropsychiat, Okayama 7008558, Japan Okayama Univ Okayama Japan 7008558 Neuropsychiat, Okayama 7008558, Japan
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 3, volume: 79, anno: 2001,
pagine: 679 - 688
SICI:
0022-3042(200111)79:3<679:TKOMPK>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIGNAL-REGULATED KINASE; IMMEDIATE-EARLY GENE; INDUCED BEHAVIORAL SENSITIZATION; MEDIAL PREFRONTAL CORTEX; RECEPTOR MESSENGER-RNA; TRANSDUCTION CASCADE; DEPENDENT MECHANISM; NUCLEUS-ACCUMBENS; DOPAMINE; AMPHETAMINE;
Keywords:
behavioral sensitization; extracellular signal-regulated kinase; methamphetamine; mitogen-activated protein kinase phosphatase; neural plasticity; stress-activated protein kinase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Takaki, M Okayama Univ, Grad Sch Med & Dent, Dept Neuropsychiat, 2-5-1 Shikata Cho, Okayama 7008558, Japan Okayama Univ 2-5-1 Shikata Cho Okayama Japan 7008558 558, Japan
Citazione:
M. Takaki et al., "Two kinds of mitogen-activated protein kinase phosphatases, MKP-1 and MKP-3, are differentially activated by acute and chronic methamphetamine treatment in the rat brain", J NEUROCHEM, 79(3), 2001, pp. 679-688

Abstract

Two functionally different MAP kinase phosphatases (MKPs) were investigated to clarify their roles in behavioral sensitization to methamphetamine (METH). Mkr-1 mRNA levels increased substantially by about 60-300% in a range of brain regions, including several cortices, the striatum and thalamus 0.5-1 h after acute METH administration. After chronic METH administration itsincrease was less pronounced, but a more than 50% increase was still seen in the frontal cortex. MKP-1 protein levels also increased 3 h after acute or chronic METH administration. MKP-3 mRNA levels increased by about 30-50%in several cortices, the striatum and hippocampus 1 h after acute METH administration, but only in the hippocampus CA1 after chronic METH administration. Pre-treatment with the D-1 dopamine receptor antagonist, SCH23390, attenuated the METH-induced increase of MKP-1 and MKP-3 mRNA in every brain region, while pre-treatment with the NMDA receptor antagonist, MK-801, attenuated it in some regions. These findings suggest that in METH-induced sensitization, MKP-1 and MKP-3 play important roles in the neural plastic modification in widespread brain regions in the earlier induction process, but in the later maintenance process, they do so only in restricted brain regions such as MKP-1 in the frontal cortices and MKP-3 in the hippocampus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/05/20 alle ore 12:01:33