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Titolo:
Cytokines and immune response in the tumor microenvironment
Autore:
Mocellin, S; Wang, E; Marincola, FM;
Indirizzi:
NCI, Surg Branch, NIH, Bethesda, MD 20814 USA NCI Bethesda MD USA 20814NCI, Surg Branch, NIH, Bethesda, MD 20814 USA NCI, Dept Transfus Med, Ctr Clin, NIH, Bethesda, MD 20814 USA NCI Bethesda MD USA 20814 sfus Med, Ctr Clin, NIH, Bethesda, MD 20814 USA
Titolo Testata:
JOURNAL OF IMMUNOTHERAPY
fascicolo: 5, volume: 24, anno: 2001,
pagine: 392 - 407
SICI:
1524-9557(200109/10)24:5<392:CAIRIT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-BETA; RENAL-CELL CARCINOMA; CD8(+) T-CELLS; ANTIGEN-PRESENTING CELLS; NECROSIS-FACTOR-ALPHA; MHC CLASS-II; ACTIVE SPECIFIC IMMUNOTHERAPY; TRANSIT MELANOMA METASTASES; INTERFERON-GAMMA-PRODUCTION; COLONY-STIMULATING FACTOR;
Keywords:
cytokine; tumor; immune response; immunotherapy;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
218
Recensione:
Indirizzi per estratti:
Indirizzo: Marincola, FM NCI, Surg Branch, NIH, Bldg 10,Room 2B58,10 Ctr Dr, Bethesda, MD 20814 USA NCI Bldg 10,Room 2B58,10 Ctr Dr Bethesda MD USA 20814 14 USA
Citazione:
S. Mocellin et al., "Cytokines and immune response in the tumor microenvironment", J IMMUNOTH, 24(5), 2001, pp. 392-407

Abstract

Over the last few decades a wealth of evidence has been gathered on the potential role that the immune system (IS) can play in the fight against cancer. Together with cell surface adhesion molecules, cytokines (CKs) mediate the activities of IS cells. Therefore, CK kinetics may represent a mirror of the immunologic phenomena occurring in the tumor microenvironment, where immune and malignant cells interact. Yet, CKs are currently used in a clinical setting to polarize the immune response against cancer. Despite the large amount of information available on IS physiology. little is known about the role of CKs in modulating the effectiveness of immunotherapy clinical trials aimed at the treatment of patients with cancer. This underscores our relative ignorance about the complex cascade of events that lead to tumor rejection. Here, we review the properties of some CKs believed to be particularly relevant to tumor immunology (i.e.. interleukin [IL]-10, transforminggrowth factor-beta, interferon-gamma. IL-2, IL-4, and IL-12). We summarized the experience gained with these CKs in vitro, in animal models. and in human beings to illustrate the achievements, the controversies, and the challenges that characterize this fascinating field of oncology. In addition, we added a short section in which a broad view of CKs released in the tumor microenvironment is proposed to underline the variety of factors that contribute to the complexity of tumor-IS interactions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:01:50