Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Carcinogen-induced inflammation and immunosuppression are enhanced in xeroderma pigmentosum group A model mice associated with hyperproduction of prostaglandin E-2
Autore:
Miyauchi-Hashimoto, H; Kuwamoto, K; Urade, Y; Tanaka, K; Horio, T;
Indirizzi:
Kansai Med Univ, Dept Dermatol, Moriguchi, Osaka 5708507, Japan Kansai MedUniv Moriguchi Osaka Japan 5708507 guchi, Osaka 5708507, Japan Osaka Biosci Inst, Dept Mol Behav Biol, Osaka, Japan Osaka Biosci Inst Osaka Japan i Inst, Dept Mol Behav Biol, Osaka, Japan Osaka Univ, Inst Mol & Cellular Biol, Osaka, Japan Osaka Univ Osaka Japan aka Univ, Inst Mol & Cellular Biol, Osaka, Japan
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 9, volume: 166, anno: 2001,
pagine: 5782 - 5791
SICI:
0022-1767(20010501)166:9<5782:CIAIAE>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ULTRAVIOLET-RADIATION; CONTACT HYPERSENSITIVITY; IMMUNE SUPPRESSION; LANGERHANS CELLS; DNA-DAMAGE; IMMUNOLOGICAL-UNRESPONSIVENESS; CYTOKINE PRODUCTION; IRRADIATED MICE; IN-VITRO; REPAIR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Miyauchi-Hashimoto, H Kansai Med Univ, Dept Dermatol, Fumizono Cho 10-15, Moriguchi, Osaka 5708507, Japan Kansai Med Univ Fumizono Cho 10-15 Moriguchi Osaka Japan 5708507
Citazione:
H. Miyauchi-Hashimoto et al., "Carcinogen-induced inflammation and immunosuppression are enhanced in xeroderma pigmentosum group A model mice associated with hyperproduction of prostaglandin E-2", J IMMUNOL, 166(9), 2001, pp. 5782-5791

Abstract

Xeroderma pigmentosum group A (XPA) gene-deficient mice easily developed skin cancers by the application of topical chemical carcinogens as well as by UV irradiation. As certain chemical carcinogens have been shown to be immunosuppressive, we examined the inflammatory and immunosuppressive effects of dimethylbenz(a)anthracene (DMBA) on XPA mice. Compared with wild-type mice, XPA mice showed greater ear swelling and reduction of epidermal Langerhans cells after DMBA application. Topical application of DMBA impaired the induction of contact hypersensitivity, initiated either locally or at distant sites. These DMBA-induced local and systemic immunosuppressions were more greatly enhanced in XPA mice than in wild-type mice. DMBA application induced pronounced production of PGE(2), IL-10, and TNF-alpha in the skin of XPA mice. Treatment with indomethacin, a potent inhibitor of PG biosynthesis, inhibited DMBA-induced inflammation and local immunosuppression. In XPA mice, increased serum IL-10 was detected after DMBA treatment. Excess production of PGE(2), TNF-alpha, and IL-10 after DMBA application may be involvedin the enhanced local and systemic immunosuppression in DMBA-treated XPA mice. Susceptibility to DMBA-induced skin tumors in XPA mice may be due to easy impairment of the immune system by DMBA in addition to a defect in the repair of DMBA-DNA adduct. Enhanced immunosuppression by chemical carcinogens as well as the mutagenicity of these mutagens might be associated with the high incidence of internal malignancies seen in XP patients. Moreover, these results supported the hypothesis that persistent DNA damage is a trigger for the production of immunoregulatory cytokines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 10:07:11