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Titolo:
TCRA gene rearrangement in immature thymocytes in absence of CD3, pre-TCR,and TCR signaling
Autore:
Mancini, SJC; Candeias, SM; Di Santo, JP; Ferrier, P; Marche, PN; Jouvin-Marche, E;
Indirizzi:
Univ Grenoble 1, INSERM, Dept Biol Mol & Struct, Lab Immunochim,Commissariat Energie Atom G,U548, F-38054 Grenoble, France Univ Grenoble 1 GrenobleFrance F-38054 G,U548, F-38054 Grenoble, France Inst Pasteur, Dept Immunol, Unite cytokines & Dev Lymhoide, F-75724 Paris,France Inst Pasteur Paris France F-75724 s & Dev Lymhoide, F-75724 Paris,France INSERM, Ctr Immunol Marseille Luminy, F-13258 Marseille, France INSERM Marseille France F-13258 seille Luminy, F-13258 Marseille, France
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 8, volume: 167, anno: 2001,
pagine: 4485 - 4493
SICI:
0022-1767(20011015)167:8<4485:TGRIIT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL-RECEPTOR; ALPHA-BETA; V(D)J RECOMBINATION; LINEAGE COMMITMENT; ALPHA/DELTA LOCUS; DEVELOPMENTAL REGULATION; ACCESSIBILITY CONTROL; THYMIC DEVELOPMENT; TARGETED MUTATION; DELTA-ENHANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Candeias, SM Univ Grenoble 1, INSERM, Dept Biol Mol & Struct, Lab Immunochim,Commissariat Energie Atom G,U548, 17 Rue Martyrs, F-38054 Grenoble, France Univ Grenoble 1 17 Rue Martyrs Grenoble France F-38054 rance
Citazione:
S.J.C. Mancini et al., "TCRA gene rearrangement in immature thymocytes in absence of CD3, pre-TCR,and TCR signaling", J IMMUNOL, 167(8), 2001, pp. 4485-4493

Abstract

During thymocyte differentiation, TCRA genes are massively rearranged onlyafter productively rearranged TCRB genes are expressed in association withpT alpha and CD3 complex molecules within a pre-TCR. Signaling from the pre-TCR via the CD3 complex Is thought to be required to promote TCRA gene accessibility and recombination. However, alpha beta (+) thymocytes do develop in pT alpha -deficient mice, showing that TCR alpha -chain genes are rearranged, either in CD4(-)CD8(-) or CD4(+)CD8(+) thymocytes, in the absence of pre-TCR expression. In this study, we analyzed the TCRA gene recombination status of early immature thymocytes in mutant mice with arrested thymocyte development, deficient for either CD3 or pT alpha and gammac expression. ADV genes belonging to different families were found rearranged to multipleAJ segments in both cases. Thus, TCRA gene rearrangement is independent ofCD3 and gammac signaling. However, CD3 expression was found to play a rolein transcription of rearranged TCR alpha -chain genes in CD4-CD8- thymocytes. Taken together, these results provide new insights into the molecular control of early T cell differentiation.

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Documento generato il 23/09/20 alle ore 21:44:28