Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Inhibition of the death receptor pathway by cFLIP confers partial engraftment of MHC class I-deficient stem cells and reduces tumor clearance in perforin-deficient mice
Autore:
Taylor, MA; Chaudhary, PM; Klem, J; Kumar, V; Schatzle, JD; Bennett, M;
Indirizzi:
Univ Texas, SW Med Ctr Dallas, Dept Pathol, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 Dallas, Dept Pathol, Dallas, TX 75390 USA Univ Texas, SW Med Ctr Dallas, Grad Program Immunol, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 Grad Program Immunol, Dallas, TX 75390 USA Univ Texas, SW Med Ctr Dallas, Dept Internal Med, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 s, Dept Internal Med, Dallas, TX 75390 USA Univ Chicago, Dept Pathol, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 ago, Dept Pathol, Chicago, IL 60637 USA
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 8, volume: 167, anno: 2001,
pagine: 4230 - 4237
SICI:
0022-1767(20011015)167:8<4230:IOTDRP>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; DOMAIN-CONTAINING RECEPTOR; HEMATOPOIETIC PROGENITOR CELLS; APOPTOSIS-MEDIATING RECEPTOR; NECROSIS-FACTOR RECEPTOR; HUMAN NK CELLS; BONE-MARROW; GROWTH-FACTOR; CONTAINING PROTEIN; MOLECULAR-CLONING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Taylor, MA Univ Texas, SW Med Ctr Dallas, Dept Pathol, 5323 Harry Hines Blvd, Dallas,TX 75390 USA Univ Texas 5323 Harry Hines Blvd Dallas TX USA 75390 75390 USA
Citazione:
M.A. Taylor et al., "Inhibition of the death receptor pathway by cFLIP confers partial engraftment of MHC class I-deficient stem cells and reduces tumor clearance in perforin-deficient mice", J IMMUNOL, 167(8), 2001, pp. 4230-4237

Abstract

NK cells mediate acute rejection of MHC class I-deficient bone marrow cell(BMC) grafts. However, the exact cytotoxic mechanisms of NK cells during acute BMC graft rejection are not well defined. Although the granule exocytosis pathway plays a major role in NK cell-mediated rejection, alternative perforin-independent mechanisms also exist. By analyzing the anti-apoptotic effects of cellular Fas-associated death domain-like IL-1-converting enzyme-inhibitory protein (cFLIP) overexpression, we investigated the possible role of death receptor-induced apoptosis in NK cell-mediated cytotoxicity. Inthe absence of perforin, we found that cFLIP overexpression reduces lysis of tumor cells by NK cells in vitro and in vivo. In addition, perforin-deficient NK cells were impaired in their ability to acutely reject cFLIP-overexpressing TAP-I knockout stem cells. These results emphasize the importanceof NK cell death receptor-mediated killing during BMC grafts in the absence of perforin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 11:27:07