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Titolo:
Use of intravenous gamma globulins in neuroimmunologic diseases
Autore:
Latov, N; Chaudhry, V; Koski, CL; Lisak, RP; Apatoff, BR; Hahn, AF; Howard, JF;
Indirizzi:
Columbia Univ, New York, NY USA Columbia Univ New York NY USAColumbia Univ, New York, NY USA
Titolo Testata:
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
fascicolo: 4, volume: 108, anno: 2001, supplemento:, S
pagine: S126 - S132
SICI:
0091-6749(200110)108:4<S126:UOIGGI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIFOCAL MOTOR NEUROPATHY; GUILLAIN-BARRE-SYNDROME; INFLAMMATORY DEMYELINATING POLYNEUROPATHY; EXPERIMENTAL AUTOIMMUNE NEURITIS; AMYOTROPHIC-LATERAL-SCLEROSIS; PLACEBO-CONTROLLED TRIAL; IMMUNOGLOBULIN TREATMENT; IMMUNE GLOBULIN; DOUBLE-BLIND; MULTIPLE-SCLEROSIS;
Keywords:
intravenous gamma globulin; peripheral neuropathy; neuropathy; chronic inflammatory demyelinating polyneuropathy; Guillain-Barre syndrome; inflammatory neuropathy; neuroimmunology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Latov, N Peripheral Neuropathy Ctr, 635 Madison Ave,Sutie 400, New York, NY 10022 USA Peripheral Neuropathy Ctr 635 Madison Ave,Sutie 400 New York NYUSA 10022
Citazione:
N. Latov et al., "Use of intravenous gamma globulins in neuroimmunologic diseases", J ALLERG CL, 108(4), 2001, pp. S126-S132

Abstract

Intravenous gamma globulin (IVIg) is used in the treatment of immunologic diseases that affect the entire neuroaxis, including the brain, spinal cord, peripheral nerves, muscles, and neuromuscular junction. The panel reviewed the available literature on the use of IVIg in order to evaluate the efficacy of this therapy in neuroimmunologic diseases. In prospective, rigorously controlled, double-blinded clinical trials, IVIg was found to have proven efficacy in the Guillain-Barre syndrome, chronic inflammatory demyelinating polyneuropathy, multifocal motor neuropathy, dermatomyositis, and Lambert-Eaton myasthenic syndrome. It was found to be probably effective in myasthenia gravis and polymyositis, and possibly effective in several other neuroimmunologic diseases. Further studies are needed to evaluate the use of IVIg for neuroimmunologic diseases in which its efficacy is suspected but notproven and to elucidate its mechanisms of action.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 17:58:00