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Titolo:
Signal transduction mechanisms and behavioral sensitization to stimulant drugs: An overview of cAMP and PLA(2)
Autore:
Gelowitz, DL; Berger, SP;
Indirizzi:
Yale Univ, Sch Med, Neurobiol Sect, New Haven, CT 06510 USA Yale Univ NewHaven CT USA 06510 Neurobiol Sect, New Haven, CT 06510 USA Univ Cincinnati, Med Ctr, Dept Psychiat, Cincinnati, OH 45267 USA Univ Cincinnati Cincinnati OH USA 45267 sychiat, Cincinnati, OH 45267 USA Univ Cincinnati, Med Ctr, Dept Neurosci, Cincinnati, OH 45267 USA Univ Cincinnati Cincinnati OH USA 45267 eurosci, Cincinnati, OH 45267 USA
Titolo Testata:
JOURNAL OF ADDICTIVE DISEASES
fascicolo: 3, volume: 20, anno: 2001,
pagine: 33 - 42
SICI:
1055-0887(2001)20:3<33:STMABS>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; VENTRAL TEGMENTAL AREA; D-AMPHETAMINE CHALLENGE; INDEPENDENT PHOSPHOLIPASE A(2); INDUCED STEREOTYPED BEHAVIORS; CYCLIC-AMP SYSTEM; PROTEIN-KINASE-A; NUCLEUS-ACCUMBENS; LOCOMOTOR SENSITIZATION; GLUCOCORTICOID RECEPTOR;
Keywords:
behavioral sensitization; cAMP; PLA(2); stimulants; cocaine; amphetamine; drug addiction; craving; signal transduction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Gelowitz, DL Yale Univ, Sch Med, Neurobiol Sect, 333 Cedar St,Room SHM B408, New Haven,CT 06510 USA Yale Univ 333 Cedar St,Room SHM B408 New Haven CTUSA 06510 A
Citazione:
D.L. Gelowitz e S.P. Berger, "Signal transduction mechanisms and behavioral sensitization to stimulant drugs: An overview of cAMP and PLA(2)", J ADDICT D, 20(3), 2001, pp. 33-42

Abstract

Behavioral sensitization refers to the progressive increase of behavioral responses to psychomotor stimulants, which provides a model for the intensification of drug craving and relapse alleged to underlie addiction in humans. Mechanisms related to sensitization may also contribute to schizophreniaand bipolar disorder. While the phenomenon has been observed for years, only recently have molecular or intracellular mechanisms associated with behavioral sensitization been studied. An overview of cAMP and PLA(2) (intracellular, signal transduction mechanisms) relevant to behavioral sensitizationwill be presented. (C) 2001 by The Haworth Press, Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 05:20:15