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Titolo:
Toward a molecular understanding of psychostimulant actions using genetically engineered dopamine receptor knockout mice as model systems
Autore:
Zhang, JH; Xu, M;
Indirizzi:
Univ Cincinnati, Coll Med, Dept Cell Biol Neurobiol & Anat, Cincinnati, OH45267 USA Univ Cincinnati Cincinnati OH USA 45267 l & Anat, Cincinnati, OH45267 USA
Titolo Testata:
JOURNAL OF ADDICTIVE DISEASES
fascicolo: 3, volume: 20, anno: 2001,
pagine: 7 - 18
SICI:
1055-0887(2001)20:3<7:TAMUOP>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; BEHAVIORAL SENSITIZATION; NUCLEUS-ACCUMBENS; MUTANT MICE; EXTRACELLULAR DOPAMINE; PSYCHOMOTOR STIMULANT; COCAINE TREATMENT; AMPHETAMINE; EXPRESSION; RESPONSES;
Keywords:
dopamine; receptor; knockout mice; cocaine; amphetamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Xu, M Univ Cincinnati, Coll Med, Dept Cell Biol Neurobiol & Anat, 3125 Eden Ave,Cincinnati, OH 45267 USA Univ Cincinnati 3125 Eden Ave Cincinnati OH USA 45267 , OH 45267 USA
Citazione:
J.H. Zhang e M. Xu, "Toward a molecular understanding of psychostimulant actions using genetically engineered dopamine receptor knockout mice as model systems", J ADDICT D, 20(3), 2001, pp. 7-18

Abstract

A major focus in studying the progression and prevention of addictive diseases has been to understand the molecular and cellular mechanisms underlying drug addiction. The brain dopaminergic system plays a central role in reward and motivation and is thought to be the main neural substrate for the actions of abusive drugs. We have used the gene targeting technology to generate dopamine D1 and D3 receptor knockout mice and used these mice as modelsystems to gain a molecular understanding of acute effects of psychostimulants cocaine and amphetamine. The use of a combined approach involving behavioral, electrophysiological as well as molecular studies has allowed us todefine initially the roles of dopamine D I and D3 receptors in the acute effects of psychostimulants and will enable us to understand mechanisms underlying their chronic actions in the future. (C) 2001 by The Haworth Press, Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:46:20