Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Tumor size and oxygenation are independent predictors of nodal disease in patients with cervix cancer
Autore:
Pitson, G; Fyles, A; Milosevic, M; Wylie, J; Pintilie, M; Hill, R;
Indirizzi:
Princess Margaret Hosp, Dept Radiat Oncol, Ontario Canc Inst, Toronto, ON M5G 2M9, Canada Princess Margaret Hosp Toronto ON Canada M5G 2M9 onto, ON M5G 2M9, Canada Princess Margaret Hosp, Dept Biostat, Ontario Canc Inst, Toronto, ON M5G 2M9, Canada Princess Margaret Hosp Toronto ON Canada M5G 2M9 onto, ON M5G 2M9, Canada Princess Margaret Hosp, Dept Expt Therapeut, Ontario Canc Inst, Toronto, ON M5G 2M9, Canada Princess Margaret Hosp Toronto ON Canada M5G 2M9 onto, ON M5G 2M9, Canada
Titolo Testata:
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
fascicolo: 3, volume: 51, anno: 2001,
pagine: 699 - 703
SICI:
0360-3016(20011101)51:3<699:TSAOAI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
SQUAMOUS-CELL CARCINOMA; UTERINE CERVIX; GENOMIC INSTABILITY; GENETIC INSTABILITY; RADIATION RESPONSE; HYPOXIA; PROGRESSION; METASTASES; SELECTION; MICROENVIRONMENT;
Keywords:
hypoxia; metastasis; tumor size; prognostic factor; cervix cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Fyles, A Princess Margaret Hosp, Dept Radiat Oncol, Ontario Canc Inst, 610Univ Ave, Toronto, ON M5G 2M9, Canada Princess Margaret Hosp 610 Univ Ave Toronto ON Canada M5G 2M9 ada
Citazione:
G. Pitson et al., "Tumor size and oxygenation are independent predictors of nodal disease in patients with cervix cancer", INT J RAD O, 51(3), 2001, pp. 699-703

Abstract

Purpose: To determine the relationships between tumor oxygenation and nodal stage in a prospective study of patients with cervix cancer, controlling for other prognostic factors. Methods and Materials: Between 1994 and 1999, 128 eligible patients with cervix cancer were entered into a prospective study of tumor oxygenation assessed by Eppendorf oxygen electrode before primary radiation therapy. Oxygenation was evaluated using the proportion of pO(2) values < 5 mmHg (HP5), and tumors were classified as hypoxic if the HP5 was > 50%. Patients were assigned to one of three groups: those with no imaging evidence of nodal (pelvic or para-aortic) or distant metastatic disease (N group; n = 67), those with equivocal findings (E group; n = 28), and those with nodal or distant metastatic disease (P group; n = 33). Results: The proportion of hypoxic tumors in the P, E, and N groups were 67%, 50%, and 40%, respectively (p 0.014), with median HP5, values of 63%, 48%, and 36%, respectively (p = 0.0024). In a multivariate analysis including tumor size, stage, HP5 and hemoglobin, it was found that tumor size and HP5 were the only independently significant variables for the finding of metastatic disease (p = 0.009 and 0.017, respectively). Conclusion: In this patient population, there was a significantly increased risk of nodal or distant metastases in patients with hypoxic tumors, and this finding was independent of tumor size. These results are consistent with the hypothesis that tumor hypoxia is an adverse prognostic factor associated with selection for a metastatic phenotype. (C) 2001 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 08:56:35