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Titolo:
Discontinuation of lithium augmentation in an elderly cohort
Autore:
Fahy, S; Lawlor, BA;
Indirizzi:
St Camillus Hosp, Dept Old Age Psychiat, Limerick, Ireland St Camillus Hosp Limerick Ireland t Old Age Psychiat, Limerick, Ireland Univ Dublin Trinity Coll, Dublin 2, Ireland Univ Dublin Trinity Coll Dublin Ireland 2 rinity Coll, Dublin 2, Ireland St James Hosp, Dublin 8, Ireland St James Hosp Dublin Ireland 8St James Hosp, Dublin 8, Ireland
Titolo Testata:
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
fascicolo: 10, volume: 16, anno: 2001,
pagine: 1004 - 1009
SICI:
0885-6230(200110)16:10<1004:DOLAIA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
REFRACTORY DEPRESSION; RESISTANT DEPRESSION; UNIPOLAR DEPRESSION; CONTROLLED TRIAL; OLD-AGE; THERAPY; CARBONATE; WITHDRAWAL; FLUOXETINE; MEDICATION;
Keywords:
lithium; augmentation; discontinuation; elderly; depression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Fahy, S St Camillus Hosp, Dept Old Age Psychiat, Shelbourne Rd, Limerick, Ireland St Camillus Hosp Shelbourne Rd Limerick Ireland imerick, Ireland
Citazione:
S. Fahy e B.A. Lawlor, "Discontinuation of lithium augmentation in an elderly cohort", INT J GER P, 16(10), 2001, pp. 1004-1009

Abstract

Objectives To observe the effects of gradual discontinuation of lithium augmentation therapy in a group of patients over the age of 65 years and to measure the rate of relapse and to identify any factors which would predict relapse. Methods This was a naturalistic study involving 21 patients who were on lithium augmentation and whose lithium was discontinued for a variety of clinical reasons. In most cases lithium was tapered and discontinued over a period of 2-12 weeks. Demographic and other variables were collected at baseline and compared between those who remained well and those that subsequentlyrelapsed. Results Eleven patients (52.4%) relapsed following discontinuation of lithium augmentation. Those who relapsed had been on lithium for significantly longer than those who remained well off lithium (p = 0.007). There was a trend towards more hospital admissions in the relapse group (p = 0.062). Conclusions When lithium augmentation therapy is discontinued in elderly depressives over half of these patients relapse. A longer duration of prediscontinuation lithium treatment and more hospital admissions appear to be associated with increased risk of relapse. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:10:36