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Titolo:
Filaricidal efficacy of anthelmintically active cyclodepsipeptides
Autore:
Zahner, H; Taubert, A; Harder, A; von Samson-Himmelstjerna, G;
Indirizzi:
Univ Giessen, Inst Parasitol, D-35392 Giessen, Germany Univ Giessen Giessen Germany D-35392 Parasitol, D-35392 Giessen, Germany Bayer AG, R&D Agr Ctr Monheim, Business Grp Anim Hlth, D-51368 Leverkusen,Germany Bayer AG Leverkusen Germany D-51368 nim Hlth, D-51368 Leverkusen,Germany
Titolo Testata:
INTERNATIONAL JOURNAL FOR PARASITOLOGY
fascicolo: 13, volume: 31, anno: 2001,
pagine: 1515 - 1522
SICI:
0020-7519(200111)31:13<1515:FEOAAC>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
MASTOMYS-NATALENSIS; LITOMOSOIDES-CARINII; BRUGIA-MALAYI; EXPERIMENTAL CHEMOTHERAPY; ACANTHOCHEILONEMA-VITEAE; ANTIFILARIAL ACTIVITIES; BENZAZOLE DERIVATIVES; DIPETALONEMA-VITEAE; B-PAHANGI; PF1022A;
Keywords:
Litomosoides sigmodontis; Acanthocheilonema viteae; Brugia malayi; cyclodepsipeptides; Bay 44-4400; filaricidal efficacy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Zahner, H Univ Giessen, Inst Parasitol, Rudolf Buchheim Str 2, D-35392 Giessen, Germany Univ Giessen Rudolf Buchheim Str 2 Giessen Germany D-35392 many
Citazione:
H. Zahner et al., "Filaricidal efficacy of anthelmintically active cyclodepsipeptides", INT J PARAS, 31(13), 2001, pp. 1515-1522

Abstract

PF 1022A. a novel anthelmintically active cyclodepsipeptide, and Bay 44-4400, a semisynthetic derivative of PF 1022A were tested for filaricidal efficacy in Mastomys concha infected with Litomosoides sigmodontis, Acanthocheilonema viteae and Brugia malayi. The parent compound PF 1022A showed limited anti-filarial efficacy in L. sigmodontis and B. malayi infected animals. Oral doses of 5 x 100 mg/kg on consecutive days caused only a temporary decrease of microfilariaemia levels. By contrast, Bay 44-4400 was highly effective against microfilariae of all three species in single oral, subcutaneous and cutaneously applied (spot on) doses. Minimum effective doses (MED, reducing parasitaemia density by greater than or equal to 95%) determined 3 and 7 days after treatment were 3.125-6.25 and 6.25-12.5 mg/kg, respectively. Using the spot on formulation, doses of 6.25 mg/kg (L. sigmodontis), 12.5mg/kg (A. viteae) and 25 mg/kg (B. malayi) were required to cause reductions of microfilaraemia levels by greater than or equal to 95% until day 56. Adulticidal effects, determined as minimum curative doses (MCD, eliminatingadult parasites within 56 days by >95%) after single dose treatment were limited to A. viteae (MCD, 100 mg/kg independent of the route of administration). Repeated oral treatment (100 mg/kg on 5 consecutive days) killed all adult L. sigmodontis but did not affect B. malayi. However, single doses of6.25 and 25 mg/kg resulted in severe pathological alterations of intrauterine stages of L. sigmodontis and B. malayi, respectively. These alterationsmay be responsible for long-lasting reductions of microfilaraemia even when curative effects could not be achieved. (C) 2001 Australian Society for Parasitology Inc. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 13:30:43