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Titolo:
Clinical outcome of Crohn's disease: Analysis according to the Vienna Classification and clinical activity
Autore:
Veloso, FT; Ferreira, JT; Barros, L; Almeida, S;
Indirizzi:
Univ Hosp S Joao, Dept Gastroenterol, P-4200319 Oporto, Portugal Univ HospS Joao Oporto Portugal P-4200319 l, P-4200319 Oporto, Portugal Univ Porto, Dept Appl Math, P-4100 Oporto, Portugal Univ Porto Oporto Portugal P-4100 ept Appl Math, P-4100 Oporto, Portugal
Titolo Testata:
INFLAMMATORY BOWEL DISEASES
fascicolo: 4, volume: 7, anno: 2001,
pagine: 306 - 313
SICI:
1078-0998(200111)7:4<306:COOCDA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFLAMMATORY BOWEL-DISEASE; PROGNOSIS; DIAGNOSIS; COHORT; RISK;
Keywords:
Crohn's disease; clinical course; prognosis; clinical activity; Vienna Classification; inflammatory bowel disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Veloso, FT Univ Hosp S Joao, Dept Gastroenterol, P-4200319 Oporto, Portugal Univ Hosp S Joao Oporto Portugal P-4200319 9 Oporto, Portugal
Citazione:
F.T. Veloso et al., "Clinical outcome of Crohn's disease: Analysis according to the Vienna Classification and clinical activity", INFLAMM B D, 7(4), 2001, pp. 306-313

Abstract

The aim of this study was to describe the clinical course of Crohn's disease (CD) in a well-defined, homogeneous groups of patients. A total of 480 patients with CD were followed up from diagnosis up to 20 years. Definitionsof patient subgroups were made according to the Vienna Classification. Markov chain analysis was used to estimate the probabilities of remissions andrelapses during the disease course. Both age at diagnosis and behavior were associated with different disease locations. Patients with ileal disease had a greater need for surgical and a lesser need for immunosuppressive treatment; patients with ileocolonic disease were diagnosed at an earlier age and showed a lower probability of remaining in remission during the diseasecourse; patients with colonic disease needed less surgical or steroid treatments; patients with intestinal penetrating disease were frequently submitted to abdominal surgery, whereas those with anal-penetrating disease oftenneeded immunosuppressive treatment. Approximately 40% of the patients werein clinical remission at any time, but only about 10% maintained a long-term remission free of steroids after their initial presentation. A more benign clinical course could be predicted in patients who stay in remission in the year after diagnosis. The grouping of patients with CD according to theVienna Classification and/or the clinical activity in the year after diagnosis is useful in predicting the subsequent course of disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 06:40:32