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Titolo:
Neuropeptides modulate a murine monocyte/macrophage cell line capacity forphagocytosis and killing of Leishmania major parasites
Autore:
Ahmed, AA; Wahbi, AH; Nordlind, K;
Indirizzi:
Karolinska Hosp, Dept Dermatol, S-17176 Stockholm, Sweden Karolinska HospStockholm Sweden S-17176 atol, S-17176 Stockholm, Sweden Huddinge Hosp, Dept Clin Immunol, S-14168 Huddinge, Sweden Huddinge Hosp Huddinge Sweden S-14168 Immunol, S-14168 Huddinge, Sweden
Titolo Testata:
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
fascicolo: 3, volume: 23, anno: 2001,
pagine: 397 - 409
SICI:
0892-3973(2001)23:3<397:NMAMMC>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE-INTESTINAL-PEPTIDE; GENE-RELATED PEPTIDE; SUBSTANCE-P; SCHISTOSOMIASIS-MANSONI; PERITONEAL-MACROPHAGES; MONONUCLEAR-CELLS; GAMMA PRODUCTION; SOMATOSTATIN; VIP; LYMPHOCYTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Nordlind, K Karolinska Hosp, Dept Dermatol, S-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-17176 6 Stockholm, Sweden
Citazione:
A.A. Ahmed et al., "Neuropeptides modulate a murine monocyte/macrophage cell line capacity forphagocytosis and killing of Leishmania major parasites", IMMUNOPH IM, 23(3), 2001, pp. 397-409

Abstract

Host-parasite interactions and their outcome constitute a critical and challenging step in disease establishment in cutaneous leishmaniasis. In the present in vitro study we investigated the possible modulating effects of both sensory and autonomic neuropeptides that normally exist in human and mouse skin, on the uptake and leishmanicidal capacity of macrophages on Leishmania (L.) major parasites, using a monocyte/macrophage murine cell line (Raw 264.7). The sensory neuropeptides somatostatin (SOM), calcitonin gene-related peptide (CGRP) and substance P (SP) suppressed the macrophage capacityfor phagocytosing L. major promastigotes at different concentrations, 10(-10)-10(-5)M, however, the suppressive effect of SP does not reach a significant level. CGRP and SP enhanced the leishmanicidal capacity of macrophagesat 10(-7)M, and 10(-5)M, respectively, whereas SOM was without effect. Theautonomic neuropeptides vasoactive intestinal peptide (VIP) and neuropeptide Y (NPY) both suppressed the phagocytic and leishmanicidal capacities of macrophages at various concentrations, 10(-10)-10(-5)M.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 20:32:04