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Titolo:
Nitric oxide prevents the IFN-gamma/LPS-induced hepatotoxicity in a protein kinase G-independent manner
Autore:
So, HS; Jung, BH; Song, HS; Kim, MS; Park, JS; Chae, KM; Lee, JH; Chung, SY; Chae, HJ; Kim, HR; Park, R;
Indirizzi:
Wonkwang Univ, Sch Med, Dept Microbiol, Jeonbuk 570749, South Korea Wonkwang Univ Jeonbuk South Korea 570749 ol, Jeonbuk 570749, South Korea Wonkwang Univ, Sch Med, Dept Internal Med, Jeonbuk 570749, South Korea Wonkwang Univ Jeonbuk South Korea 570749 ed, Jeonbuk 570749, South Korea Wonkwang Univ, Sch Med, Dept Surg, Jeonbuk 570749, South Korea Wonkwang Univ Jeonbuk South Korea 570749 rg, Jeonbuk 570749, South Korea Wonkwang Univ, Sch Med, Dept Otolaryngol, Jeonbuk 570749, South Korea Wonkwang Univ Jeonbuk South Korea 570749 ol, Jeonbuk 570749, South Korea Wonkwang Univ, Sch Med, Dept Dent Pharmacol, Sch Dent, Jeonbuk 570749, South Korea Wonkwang Univ Jeonbuk South Korea 570749 nt, Jeonbuk 570749, South Korea Chonnam Natl Univ, Sch Med, Dept Surg, Kwanju 501757, South Korea Chonnam Natl Univ Kwanju South Korea 501757 , Kwanju 501757, South Korea
Titolo Testata:
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
fascicolo: 3, volume: 23, anno: 2001,
pagine: 321 - 334
SICI:
0892-3973(2001)23:3<321:NOPTIH>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
GALACTOSAMINE-SENSITIZED MICE; NECROSIS-FACTOR-ALPHA; INTERFERON-GAMMA; HEPATIC-INJURY; L-ARGININE; LIVER; LIPOPOLYSACCHARIDE; MECHANISMS; MESSENGER; CYTOKINES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Park, R Wonkwang Univ, Sch Med, Dept Microbiol, 344-2 Shinyong Dong Iksan,Jeonbuk570749, South Korea Wonkwang Univ 344-2 Shinyong Dong Iksan Jeonbuk South Korea 570749
Citazione:
H.S. So et al., "Nitric oxide prevents the IFN-gamma/LPS-induced hepatotoxicity in a protein kinase G-independent manner", IMMUNOPH IM, 23(3), 2001, pp. 321-334

Abstract

Although it has been well known that the role of LPS on hepatotoxicity is mediated through TNF-alpha, the direct cytotoxic effect of LPS on IFN-gamma-primed hepatocytes has not yet been clearly demonstrated. Here, we demonstrate that the IFN-gamma -mediated death of murine embryonic liver BNL CL2 cells is potentiated by LPS (0.5 mug/ml). In addition, an exogenous NO donor, sodium nitroprusside (SNP) significantly prevents cell death induced by IFN-gamma alone or IFN-gamma plus LPS (IFN-gamma /LPS) in a dose-dependent manner over 25 muM. SNP significantly blocked the death of BNL CL2 cells only when it was added within 12 hr after treatment of IFN-gamma and IFN-gamma /LPS. The preventive effect of SNP occurred in parallel with the suppression of caspase 3-like protease activation. We have also demonstrated that arelatively high concentration as well as an appropriate period of exposureto NO may be critical to maintain cell viability from the cytotoxic effectof IFN-gamma and IFN-gamma /LPS. Furthermore, the preventive effect of SNPon IFN-gamma /LPS-induced cell death is mediated by a protein kinase G (PKG)-independent manner.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 17:48:28