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Titolo:
p27: A potential main inhibitor of cell proliferation in digestive endocrine tumors but not a marker of benign behavior
Autore:
Canavese, G; Azzoni, C; Pizzi, S; Corleto, VD; Pasquali, C; Davoli, C; Crafa, P; Delle Fave, G; Bordi, C;
Indirizzi:
Univ Parma, Sect Pathol Anat, Dept Pathol & Lab Med, I-43100 Parma, Italy Univ Parma Parma Italy I-43100 pt Pathol & Lab Med, I-43100 Parma, Italy Univ Roma La Sapienza, Sch Med 2, Dept Digest Dis, I-00185 Rome, Italy Univ Roma La Sapienza Rome Italy I-00185 Digest Dis, I-00185 Rome, Italy Univ Roma La Sapienza, Dept Cell Biotechnol & Hematol, I-00185 Rome, ItalyUniv Roma La Sapienza Rome Italy I-00185 & Hematol, I-00185 Rome, Italy Univ Padua, Dept Med & Surg Sci, Surg Unit, I-35100 Padua, Italy Univ Padua Padua Italy I-35100 Surg Sci, Surg Unit, I-35100 Padua, Italy Hosp Pathol Serv, Castelfranco Veneto, Italy Hosp Pathol Serv Castelfranco Veneto Italy , Castelfranco Veneto, Italy
Titolo Testata:
HUMAN PATHOLOGY
fascicolo: 10, volume: 32, anno: 2001,
pagine: 1094 - 1101
SICI:
0046-8177(200110)32:10<1094:PAPMIO>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
PANCREATIC NEUROENDOCRINE TUMORS; DEPENDENT KINASE INHIBITORS; SUPPRESSOR GENE; PROGNOSTIC-SIGNIFICANCE; P27(KIP1) EXPRESSION; CARCINOID-TUMORS; NUCLEAR ANTIGEN; PROTEIN; P53; IMMUNOREACTIVITY;
Keywords:
cyclin-dependent kinase inhibitors; p27(Kip1); p21(Waf1); Ki67; cell proliferation; pancreatic endocrine tumors; gastrointestinal carcinoids;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Bordi, C Univ Parma, Sect Pathol Anat, Dept Pathol & Lab Med, I-43100 Parma, Italy Univ Parma Parma Italy I-43100 & Lab Med, I-43100 Parma, Italy
Citazione:
G. Canavese et al., "p27: A potential main inhibitor of cell proliferation in digestive endocrine tumors but not a marker of benign behavior", HUMAN PATH, 32(10), 2001, pp. 1094-1101

Abstract

The immunohistochemical expression of the inhibitors of cyclin-dependent kinases p21 and p27 was investigated in 109 endocrine tumors of the pancreasand gastrointestinal tract and compared with that of Ki67 and p53. p21 wasfound to be scarcely expressed without significant differences between benign and malignant or between differentiated and undifferentiated tumors. This suggests no relationship between changes in p21 levels and clinical behavior in these endocrine tumors. p27 was found to be highly expressed in differentiated neoplasms and proved to be inversely related to Ki67 labeling (P = .02), which was usually low. These data indicate that p27 may have an important inhibiting role on the low proliferation rate of the tumors. Moreover, the protein may have a role in the resistance of differentiated endocrine tumors to chemotherapeutic agents. p27 high-expressor neoplasms were frequent in either benign (70.6%) or malignant (81.4%) differentiated tumors,thus not allowing the use of this protein for the differential diagnosis of malignant neoplasms as suggested for endocrine tumors of parathyroid. andpituitary. Poorly differentiated endocrine carcinomas, which differred from the differentiated tumors for their very high Ki67 levels and frequent p53 expression, showed low or absent p21 and p27 in most cases. Classical. midgut carcinoids were characterized by a sharp discrepancy between malignantbehavior and very bland proliferative pattern, with Ki67 and p27 expressions similar to that of benign tumors. H-UM PATHOL 32:1094-1101. Copyright (C) 2001 by W.B. Saunders Company.

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Documento generato il 30/11/20 alle ore 06:47:19