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Titolo:
Bcl2-L-10, a novel anti-apoptotic member of the Bcl-2 family, blocks apoptosis in the mitochondria death pathway but not in the death receptor pathway
Autore:
Zhang, H; Holzgreve, W; De Geyter, C;
Indirizzi:
Univ Womens Hosp Basel, CH-4031 Basel, Switzerland Univ Womens Hosp BaselBasel Switzerland CH-4031 4031 Basel, Switzerland
Titolo Testata:
HUMAN MOLECULAR GENETICS
fascicolo: 21, volume: 10, anno: 2001,
pagine: 2329 - 2339
SICI:
0964-6906(20011002)10:21<2329:BANAMO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED CELL-DEATH; IN-VIVO PATTERNS; IMMUNOHISTOCHEMICAL ANALYSIS; DEFICIENT MICE; BH3 DOMAIN; BAX; PROTEIN; EXPRESSION; INHIBITION; HETERODIMERIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Zhang, H Univ Womens Hosp Basel, Schanzentstr 46, CH-4031 Basel, Switzerland Univ Womens Hosp Basel Schanzentstr 46 Basel Switzerland CH-4031
Citazione:
H. Zhang et al., "Bcl2-L-10, a novel anti-apoptotic member of the Bcl-2 family, blocks apoptosis in the mitochondria death pathway but not in the death receptor pathway", HUM MOL GEN, 10(21), 2001, pp. 2329-2339

Abstract

By GenBank database searches and PCR, we have identified a novel human Bcl2-like gene, Bcl2-L-10, which contains conserved BH4, BH1 and BH2 domains but lacks BH3 domain. The Bcl2-L-10 gene has been assigned to chromosome 15q21.2. Transfection experiments demonstrated that Bcl2-L-10 can block apoptosis induced by interleukin-3 withdrawal and Bax expression, by prevention of cytochrome C release, caspase-3 activation and mitochondrial membrane potential collapse. Bcl2-L-10 cannot block TNF alpha -induced apoptosis. Furthermore, both the BH4 domain and the transmembrane domain of Bcl2-L-10 are necessary for its suppressive action on cell death. Our results demonstratedthat Bcl2-L-10 is a newly detected anti-apoptotic member of the Bcl-2 family and that it blocks apoptosis in the mitochondrial death pathway but not in the death receptor pathway.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 19:38:28