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Titolo:
Chemotherapy-induced erythema nodosum leprosum: successful treatment with thalidomide
Autore:
Petering, H; Kiehl, P; Vogelbruch, M; Sticht-Groh, V; Kapp, A; Werfel, T;
Indirizzi:
Hannover Med Sch, Dermatol Klin & Poliklin, D-30449 Hannover, Germany Hannover Med Sch Hannover Germany D-30449 lin, D-30449 Hannover, Germany
Titolo Testata:
HAUTARZT
, volume: 52, anno: 2001,
pagine: 966 - 969
SICI:
0017-8470(200110)52:<966:CENLST>2.0.ZU;2-F
Fonte:
ISI
Lingua:
GER
Keywords:
leprosy; leprosy reaction; erythema nodosum leprosum; thalidomide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Petering, H Hannover Med Sch, Dermatol Klin & Poliklin, Ricklinger Str 5, D-30449 Hannover, Germany Hannover Med Sch Ricklinger Str 5 Hannover Germany D-30449 ny
Citazione:
H. Petering et al., "Chemotherapy-induced erythema nodosum leprosum: successful treatment with thalidomide", HAUTARZT, 52, 2001, pp. 966-969

Abstract

The severity and outcome of a chronic granulomatous infection caused by M.leprae depend on the cell-mediated immunity towards the pathogen. The disease classification is based on the host's response to M. leprae ranging from high to low resistance (polar tuberculoid leprosy to polar lepromatous leprosy). The host's position in the spectrum is not stable; leprosy reactions reflecting changed immune status may occur spontaneously or during chemotherapy. The type II reaction or erythema nodosum leprosum can most often beseen in patients with lepromatous leprosy, a multiorgan disease characterized by an unrestricted bacillary replication. Clinically, this reaction is characterized by crops of painful bright pink, dermal and subcutaneous nodules arising in clinically normal skin, in association with fever, malaise, glomerulonephritis and arthralgias. Therefore, prompt institution of immunosuppressive therapy with corticosteroids or thalidomide is recommended. This case report describes the development of erythema nodosum leprosum duringchemotherapy treated successfully with thalidomide. Furthermore, immunologic effects and potential side effects of this drug are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 03:25:19