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Titolo:
Mechanisms of Bordetella pathogenesis
Autore:
Mattoo, S; Foreman-Wykert, AK; Cotter, PA; Miller, JF;
Indirizzi:
Univ Calif Los Angeles, Sch Med, Ctr Hlth Sci, Dept Microbiol Mol Genet & Immunol, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Inst Mol Biol, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA
Titolo Testata:
FRONTIERS IN BIOSCIENCE
, volume: 6, anno: 2001,
pagine: E168 - E186
SICI:
1093-9946(200111)6:<E168:MOBP>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERTUSSIS FILAMENTOUS HEMAGGLUTININ; ADENYLATE-CYCLASE TOXIN; OUTER-MEMBRANE PROTEIN; BRONCHISEPTICA DERMONECROTIC TOXIN; ISLET-ACTIVATING PROTEIN; CELL-MEDIATED-IMMUNITY; FOCAL ADHESION KINASE; TRACHEAL CYTO-TOXIN; SWISS 3T3 CELLS; PAXILLIN TYROSINE PHOSPHORYLATION;
Keywords:
bacterial pathogenesis; Bordetella; bacteria; infection; review;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
220
Recensione:
Indirizzi per estratti:
Indirizzo: Miller, JF Univ Calif Los Angeles, Sch Med, Ctr Hlth Sci, Dept Microbiol Mol Genet & Immunol, 10833 LeConte Ave, Los Angeles, CA 90095 USA Univ CalifLos Angeles 10833 LeConte Ave Los Angeles CA USA 90095
Citazione:
S. Mattoo et al., "Mechanisms of Bordetella pathogenesis", FRONT BIOSC, 6, 2001, pp. E168-E186

Abstract

Bordetella are Gram negative bacteria that cause respiratory tract infections in humans and animals. While at least five different species of Bordetella are known to exist, this review focuses on B. pertussis, B. bronchiseptica and B. parapertussis subspecies. In their virulent phase, all of these bacteria produce a nearly identical set of virulence factors which include adhesins such as filamentous hemagglutinin (FHA), fimbriae and pertactin, as well as toxins such as a bifunctional adenylate cyclase/hemolysin, dermonecrotic toxin, tracheal cytotoxin, a B. pertussis specific pertussis toxin and B. bronchiseptica specific type III secreted proteins. Expression of nearly all of these virulence factors is positively regulated by the productsof the bvgAS locus. BvgA and BvgS comprise a two-component signal transduction system that mediates transition between at least three identifiable phases --- a virulent (Bvg(+)) phase, an avirulent (Bvg(-)) phase and an intermediate (Bvg(+)) phase --- in response to specific environmental signals. Bordetella colonize the ciliated respiratory mucosa, a surface designed to eliminate foreign particles, thereby making the adherence and persistence mechanisms of these bacteria crucial. The development of relevant animal models for B. bronchiseptica has enabled us to study Bordetella pathogenesis in the context of natural host-pathogen interactions. In addition, evolutionary studies across the various Bordetella species and detailed analysis of differential regulation of Bvg-activated/repressed genes has greatly enhanced our understanding of the mechanisms of Bordetella pathogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 14:10:08