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Titolo:
Endogeneous fibrinolysis and restenosis of peripheral arteries after percutaneous transluminal angioplasty
Autore:
Kozak, M; Poredos, P;
Indirizzi:
Univ Ljubljana, Med Ctr, Dept Angiol, SI-1000 Ljubljana, Slovenia Univ Ljubljana Ljubljana Slovenia SI-1000 l, SI-1000 Ljubljana, Slovenia
Titolo Testata:
FIBRINOLYSIS & PROTEOLYSIS
fascicolo: 1, volume: 15, anno: 2001,
pagine: 21 - 25
SICI:
1369-0191(200101)15:1<21:EFAROP>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANS-LUMINAL ANGIOPLASTY; CORONARY ANGIOPLASTY; OCCLUSIVE DISEASE; FOLLOW-UP; SYSTEM; ATHEROSCLEROSIS; EXPRESSION; PROTEINS; INJURY; PTCA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Kozak, M Univ Ljubljana, Med Ctr, Dept Angiol, Riharjeva 24, SI-1000 Ljubljana, Slovenia Univ Ljubljana Riharjeva 24 Ljubljana Slovenia SI-1000 Slovenia
Citazione:
M. Kozak e P. Poredos, "Endogeneous fibrinolysis and restenosis of peripheral arteries after percutaneous transluminal angioplasty", FIBRINOL PR, 15(1), 2001, pp. 21-25

Abstract

To assess the role of the fibrinolytic system in the pathogenesis of restenosis after percutaneous transluminal angioplasty (PTA) of peripheral arteries, 166 consecutive patients with peripheral atherosclerotic disease, ranging from 36 to 86 years old (median = 60), who had undergone successful PTA, were followed for 1 year. Tissue plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1) antigens were determined before PTAand at 3, 6 and 12 months after, while t-PA activity, PAI-1 activity, fibrinogen, plasminogen, euglobulin clot lysis time and alpha2-antiplasmin weredetermined at 3 months after PTA. There were no significant differences infibrinolytic parameters between patients with patent (121 patients - 73%) and those with restenosed (45 patients - 27%) arteries. Restenosis was morecommon in patients with poor outflow (17 out of 44 patients) than with good outflow (28 out of 122 patients; P <0.05), with pre-existent occlusion (27 out of 93 patients) than with preexistent stenosis (17 out of 73 patients; P <0.05), and with symptoms lasting longer than 6 weeks (35 out of 108 patients) than with symptoms lasting less (10 out of 58 patients; P <0.05). We concluded that measured fibrinolytic parameters were not related to post-PTA restenosis, suggesting that the endogenous fibrinolytic system, estimated in peripheral blood, does not influence the development of restenosis ina peripheral artery. (C) 2001 Harcourt Publishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 02:52:05