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Titolo:
Conditional autoimmunity mediated by human natural anti-Fc epsilon RI alpha autoantibodies?
Autore:
Horn, MP; Pachlopnik, JM; Vogel, M; Dahinden, M; Wurm, F; Stadler, BM; Miescher, SM;
Indirizzi:
Inselspital Bern, Inst Immunol & Allergol, CH-3010 Bern, Switzerland Inselspital Bern Bern Switzerland CH-3010 gol, CH-3010 Bern, Switzerland Ecole Polytech Fed Lausanne, Ctr Biotechnol UNIL EPFL, Lab Cellular Biotechnol, CH-1015 Lausanne, Switzerland Ecole Polytech Fed Lausanne Lausanne Switzerland CH-1015 ne, Switzerland ZLB Bioplasma AG, CH-3022 Bern, Switzerland ZLB Bioplasma AG Bern Switzerland CH-3022 AG, CH-3022 Bern, Switzerland
Titolo Testata:
FASEB JOURNAL
fascicolo: 12, volume: 15, anno: 2001,
pagine: 2268 - 2274
SICI:
0892-6638(200110)15:12<2268:CAMBHN>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
AFFINITY IGE RECEPTOR; PASSIVE SENSITIZATION; HISTAMINE-RELEASE; DOWN-REGULATION; HUMAN BASOPHILS; PHAGE DISPLAY; IN-VIVO; ANTIBODIES; EXPRESSION; SYSTEM;
Keywords:
natural autoantibodies; phage display; IgE receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Miescher, SM Inselspital Bern, Inst Immunol & Allergol, Sahlihaus 1, CH-3010 Bern, Switzerland Inselspital Bern Sahlihaus 1 Bern Switzerland CH-3010erland
Citazione:
M.P. Horn et al., "Conditional autoimmunity mediated by human natural anti-Fc epsilon RI alpha autoantibodies?", FASEB J, 15(12), 2001, pp. 2268-2274

Abstract

Natural antibodies provide an early defense mechanism against pathogens, show a frequent self-reactivity, and are present throughout life. Two questions concern the physiological control of self-reactivity and the pathogenetic link to autoimmune disease. Here we propose a concept of conditional autoimmunity involving natural antibodies against the alpha chain of the high-affinity receptor for IgE (Fc epsilon RI alpha). Like other natural antibodies, anti-Fc epsilon RI alpha antibodies are found in sera of healthy donors. We now report the first human recombinant anti-Fc epsilon RI alpha autoantibodies isolated by repertoire cloning from a human tonsillar IgM library. These high-affinity antibodies recognize Fc epsilon RI alpha on cells andtrigger histamine release from freshly isolated blood basophils. However, the latter effect requires IgE removal from the Fc epsilon RI. The same conditional histamine release is seen when using sera from individual normal donors and affinity-purified anti-Fc epsilon RI alpha antibodies isolated from multidonor therapeutic IgG preparations. We propose that such anti-Fc epsilon RI alpha antibodies can become pathogenic and that this is dependent on the state of occupancy of the Fc epsilon RI alpha by its natural ligand IgE. We suggest that an imbalance between Fc epsilon RI alpha occupancy andnatural anti-Fc epsilon RI alpha antibodies may be implicated in the pathogenesis of autoimmune urticaria.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 08:57:59