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Titolo:
Hyaluronan serves a novel role in airway mucosal host defense
Autore:
Forteza, R; Lieb, T; Aoki, T; Savani, RC; Conner, GE; Salathe, M;
Indirizzi:
Univ Miami, Sch Med, Div Pulm & Crit Care Med R47, Miami, FL 33136 USA Univ Miami Miami FL USA 33136 lm & Crit Care Med R47, Miami, FL 33136 USA Univ Penn, Sch Med, Div Neonatol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Neonatol, Philadelphia, PA 19104 USA Univ Miami, Sch Med, Dept Cell Biol & Anat, Miami, FL 33136 USA Univ Miami Miami FL USA 33136 Dept Cell Biol & Anat, Miami, FL 33136 USA
Titolo Testata:
FASEB JOURNAL
fascicolo: 12, volume: 15, anno: 2001,
pagine: 2179 - 2186
SICI:
0892-6638(200110)15:12<2179:HSANRI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNOREACTIVE TISSUE KALLIKREIN; LOWER RESPIRATORY-TRACT; CILIARY BEAT FREQUENCY; BRONCHOALVEOLAR LAVAGE; ASTHMATIC SUBJECTS; EPITHELIAL-CELLS; BINDING-PROTEIN; RECEPTOR RHAMM; SPERM MOTILITY; GUINEA-PIG;
Keywords:
kallikrein; lactoperoxidase; cilia; epithelium; airway;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Salathe, M Univ Miami, Sch Med, Div Pulm & Crit Care Med R47, 1600 NW 10thAve,RMSB 7063, Miami, FL 33136 USA Univ Miami 1600 NW 10th Ave,RMSB 7063 Miami FL USA 33136 36 USA
Citazione:
R. Forteza et al., "Hyaluronan serves a novel role in airway mucosal host defense", FASEB J, 15(12), 2001, pp. 2179-2186

Abstract

Enzymes secreted onto epithelial surfaces play a vital role in innate mucosal defense, but are believed to be steadily removed from the surface by mechanical actions. Thus, the amount and availability of enzymes on the surface are thought to be maintained by secretion. In contrast to this paradigm,we show here that enzymes are retained at the apical surface of the airwayepithelium by binding to surface-associated hyaluronan, providing an apical enzyme pool 'ready for use' and protected from ciliary clearance. We havestudied lactoperoxidase, which prevents bacterial colonization of the airway, and kallikrein, which mediates allergic bronchoconstriction that limitsthe inhalation of noxious substances. Binding to hyaluronan inhibits kallikrein, which is needed only in certain situations, whereas lactoperoxidase,useful at all times, does not change its activity. Hyaluronan itself interacts with the receptor for hyaluronic acid-mediated motility (RHAMM or CD168) that is expressed at the apex of ciliated airway epithelial cells. Functionally, hyaluronan binding to RHAMM stimulates ciliary beating. Thus, hyaluronan plays a previously unrecognized pivotal role in mucosal host defenseby stimulating ciliary clearance of foreign material while simultaneously retaining enzymes important for homeostasis at the apical surface so that they cannot be removed by ciliary action.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 12:00:34