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Titolo:
Cyclooxygenase-independent actions of cyclooxygenase inhibitors
Autore:
Tegeder, I; Pfeilschifter, J; Geisslinger, G;
Indirizzi:
Univ Frankfurt Klinikum, Pharmazentrum Frankfurt, D-60590 Frankfurt, Germany Univ Frankfurt Klinikum Frankfurt Germany D-60590 590 Frankfurt, Germany
Titolo Testata:
FASEB JOURNAL
fascicolo: 12, volume: 15, anno: 2001,
pagine: 2057 - 2072
SICI:
0892-6638(200110)15:12<2057:CAOCI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
NF-KAPPA-B; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; COLON-CANCER CELLS; ACTIVATED RECEPTOR-GAMMA; NITRIC-OXIDE SYNTHASE; NECROSIS-FACTOR-ALPHA; TUMOR-SUPPRESSOR PROTEIN; ASPIRIN-LIKE DRUGS; PROSTAGLANDIN ENDOPEROXIDE SYNTHASES; VIRUS LATENT MEMBRANE-PROTEIN-1;
Keywords:
aspirin; NSAIDs; apoptosis; metalloproteinase;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
218
Recensione:
Indirizzi per estratti:
Indirizzo: Geisslinger, G Univ Frankfurt Klinikum, Pharmazentrum Frankfurt, Theodor Stern Kai 7, D-60590 Frankfurt, Germany Univ Frankfurt Klinikum Theodor Stern Kai 7 Frankfurt Germany D-60590
Citazione:
I. Tegeder et al., "Cyclooxygenase-independent actions of cyclooxygenase inhibitors", FASEB J, 15(12), 2001, pp. 2057-2072

Abstract

Several studies have demonstrated unequivocally that certain nonsteroidal anti-inflammatory drugs (NSAIDs) such as sodium salicylate, sulindac, ibuprofen, and flurbiprofen cause anti-inflammatory and antiproliferative effects independent of cyclooxygenase activity and prostaglandin synthesis inhibition. These effects are mediated through inhibition of certain transcription factors such as NF-kappaB and AP-1. The respective NSAIDs might interferedirectly with the transcription factors, but their effects are probably mediated predominantly through alterations of the activity of cellular kinases such as IKK beta, Erk, p38 MAPK, or Cdks. These effects apparently are not shared by all NSAIDs, since indomethacin failed to inhibit NF-kappaB and AP-1 activation as well as Erk and Cdk activity. In contrast, indomethacin was able to activate PPAR gamma, which was not affected by sodium salicylate or aspirin. The differences in cyclooxygenase-independent mechanisms may have consequences for the specific use of these drugs in individual patients because additional effects may either enhance the efficacy or reduce the toxicity of the respective compounds.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:17:48