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Titolo:
Amantadine in Parkinson's disease: lymphocyte subsets and IL-2 secreting Tcell precursor frequencies
Autore:
Tribl, GG; Wober, C; Schonborn, V; Brucke, T; Deecke, L; Panzer, S;
Indirizzi:
Univ Vienna, Clin Dept Blood Grp Serol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 lood Grp Serol, A-1090 Vienna, Austria Univ Vienna, Dept Neurol, Vienna, Austria Univ Vienna Vienna AustriaUniv Vienna, Dept Neurol, Vienna, Austria
Titolo Testata:
EXPERIMENTAL GERONTOLOGY
fascicolo: 10, volume: 36, anno: 2001,
pagine: 1761 - 1771
SICI:
0531-5565(200111)36:10<1761:AIPDLS>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
VERSUS-HOST DISEASE; CEREBROSPINAL-FLUID; 2 PARTS; INTERLEUKIN-2; ACTIVATION; EXPRESSION; BINDING; NAIVE;
Keywords:
Parkinson's disease; amantadine treatment; B cells; T cells; alloimmune response; interleukin-2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Panzer, S Univ Vienna, Clin Dept Blood Grp Serol, Wahringer Gurtel 18-20, A-1090 Vienna, Austria Univ Vienna Wahringer Gurtel 18-20 Vienna Austria A-1090 ustria
Citazione:
G.G. Tribl et al., "Amantadine in Parkinson's disease: lymphocyte subsets and IL-2 secreting Tcell precursor frequencies", EXP GERONT, 36(10), 2001, pp. 1761-1771

Abstract

The antiviral drug amantadine, that is effective in idiopathic Parkinson'sdisease (PD), may affect the composition and function of peripheral blood lymphocytes. In an explorative study, we therefore compared lymphocyte subpopulations and IL-2 secreting T cell precursors frequencies (HTLp-frequencies) in 15 PD patients without amantadine and six patients on long-term treatment. Five patients were investigated before and three months after the start of treatment. Group comparisons for long-term amantadine treatment showed no differences in subpopulations of B-, T-, and NK cells, and HTLp-frequencies. However, three months after initiation of treatment we noted in allfive patients an increase of CD3+CD4+ and decrease of CD3+CD8+ cells, associated with an increase of the CD3+CD4+/CD3+CD8+ ratio. These changes had no effect on the HTLp-frequencies. Thus, at least for a short period of time, amantadine improves the T cell mediated immune system in PD patients. (C)2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 22:38:39