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Titolo:
Effect of epristeride on the expression of IGF-1 and TGF-beta receptors inandrogen-induced castrated rat prostate
Autore:
Wu, SF; Sun, HZ; Qi, XD; Tu, ZH;
Indirizzi:
Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China Chinese Acad Sci Shanghai Peoples R China 200031 200031, Peoples R China Fudan Univ, Med Ctr, Shanghai 200032, Peoples R China Fudan Univ Shanghai Peoples R China 200032 nghai 200032, Peoples R China
Titolo Testata:
EXPERIMENTAL BIOLOGY AND MEDICINE
fascicolo: 10, volume: 226, anno: 2001,
pagine: 954 - 960
SICI:
1535-3702(200111)226:10<954:EOEOTE>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-BETA; PROGRAMMED CELL-DEATH; EPITHELIAL-CELLS; VENTRAL PROSTATE; FACTOR-I; BINDING-PROTEIN; HYPERPLASIA; INSULIN; LOCALIZATION; TISSUE;
Keywords:
epristeride; rat prostate; growth factor; immunohistochemistry; in situ hybridization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Tu, ZH Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Room 207,294 Tai Yuan Rd, Shanghai 200031, Peoples R China Chinese Acad Sci Room 207,294 Tai Yuan Rd Shanghai Peoples R China 200031
Citazione:
S.F. Wu et al., "Effect of epristeride on the expression of IGF-1 and TGF-beta receptors inandrogen-induced castrated rat prostate", EXP BIOL ME, 226(10), 2001, pp. 954-960

Abstract

The development of benign prostatic hyperplasia (BPH) is an androgen-dependent process that may be mediated by a number of locally produced growth factors. Among them, insulinlike growth factor 1 (IGF-1) and transforming growth factor beta (TGF beta) are thought important in regulating prostate growth and homeostasis, and their expression undergoes changes in proliferative prostatic disease. Epristeride, a 5 alpha -reductase inhibitor, is an, effective drug in the treatment of BPH, inducing regressive changes in the prostate. This study was designed to assess the effects, of epristeride on expression of these two factors at mRNA and protein levels in castrated rats maintained with exogenous testosterone. Epristeride treatment caused significant reduction in ventral prostate weight in a dose-dependent manner. There was a positive correlation between IGF-1 mRNA expression and ventral prostate weight and an inverse, correlation between TGF-beta1 mRNA expression and ventral prostate. weight. Immunohistochemistry showed strong IGF-1 receptor immunoreactivity in the prostatic epithelial cells of untreated animals. In situ hybridization demonstrated high levels, of IGF-1 mRNA expression both in the prostatic stromal and epithelial cells, of untreated rats. In treated rats, both IGF-1 receptor protein and; IGF-1 mRNA levels decreased significantly, and IGF-1 mRNA was mainly expressed in prostatic stromal cells. Weak expression; of TGF beta receptors at the protein level and TWO at the mRNA level were found in the prostatic hyperplastic epithelial cells of untreated rats. In treated animals, intense T beta RII immunoreactivity was, observed in epithelial cells, and a higher level of TGF beta mRNA was observed in both epithelial cells and stromal cells compared with control animals. In our opinion, the effect of epristeride on rat prostatic, atrophy might be mediated via local growth factor(s).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 15:26:38