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Titolo:
Attenuated agonist evoked vasoconstrictor responses in the perfused mesenteric vascular bed of streptozotocin diabetic rats
Autore:
Misurski, DA; Hopfner, RL; Gopalakrishnan, V;
Indirizzi:
Univ Saskatchewan, Coll Med, Dept Pharmacol, Saskatoon, SK S7N 5E5, CanadaUniv Saskatchewan Saskatoon SK Canada S7N 5E5 skatoon, SK S7N 5E5, Canada Univ Saskatchewan, Coll Med, Cardiovasc Risk Factor Reduct Unit, Saskatoon, SK S7N 5E5, Canada Univ Saskatchewan Saskatoon SK Canada S7N 5E5 skatoon, SK S7N 5E5, Canada
Titolo Testata:
EXPERIMENTAL BIOLOGY AND MEDICINE
fascicolo: 10, volume: 226, anno: 2001,
pagine: 940 - 946
SICI:
1535-3702(200111)226:10<940:AAEVRI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTERIAL BED; CONTRACTILE RESPONSES; NITRIC-OXIDE; ENDOTHELIN-1; MELLITUS; INSULIN; RESPONSIVENESS; AORTA; ALPHA-1-ADRENOCEPTOR; STIMULATION;
Keywords:
G protein; vascular smooth muscle; diabetes; mesenteric vascular bed;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Gopalakrishnan, V Univ Saskatchewan, Coll Med, Dept Pharmacol, Saskatoon, SK S7N 5E5, Canada Univ Saskatchewan Saskatoon SK Canada S7N 5E5 5, Canada
Citazione:
D.A. Misurski et al., "Attenuated agonist evoked vasoconstrictor responses in the perfused mesenteric vascular bed of streptozotocin diabetic rats", EXP BIOL ME, 226(10), 2001, pp. 940-946

Abstract

We compared agonist-evoked responses in the perfused mesenteric, vascular bed (UVB) of streptozotocin (STZ) diabetic Sprague-Dawley rats 2 and 14 weeks after induction of diabetes. Endothelin-1 (ET-1), methoxamine (MTX)-, and KCl-evoked vasoconstrictor responses were unchanged in 2-week-old diabetic rats. In contrast, both the sensitivity (P < 0.01) and the maximal vasoconstrictor responses (P < 0.05) to ET-1 were attenuated in 14-week-old diabetic rats, whereas endothelin plasma levels were increased (P < 0.05). Although no differences were observed in responses to KCl in either the 2- or 14-week-old diabetic groups, MTX-evoked maximal responses were attenuated in the 14-week-old group (P < 0.01). Changes in agonist-evoked responses in the 14-week-old diabetic group were unaffected by the protein kinase C (PKC) inhibitor, staurosporine, the phospholipase C (PLC) inhibitor, U73122, the calcium channel blocker, nifedipine, the calcium pump inhibitor, cyclopiazonic acid (CPA), or by endothelial denudation. Sodium fluoride (NaF), an activator of guanosine triphosphate binding proteins, (G proteins) normalized the responses in the 14-week-old diabetic group. These data suggest that advanced stages of STZ are associated with alterations in G protein receptor coupling and/or activity leading to the attenuation of responses to vasoconstrictor agonists.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 03:27:52