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Titolo:
Leptin-deficient mice commence hypersecreting insulin in response to acetylcholine between 1 and 2 weeks of age
Autore:
Lee, JW; Romsos, DR;
Indirizzi:
Michigan State Univ, Dept Food Sci & Human Nutr, E Lansing, MI 48824 USA Michigan State Univ E Lansing MI USA 48824 Nutr, E Lansing, MI 48824 USA
Titolo Testata:
EXPERIMENTAL BIOLOGY AND MEDICINE
fascicolo: 10, volume: 226, anno: 2001,
pagine: 906 - 911
SICI:
1535-3702(200111)226:10<906:LMCHII>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PANCREATIC-ISLETS; OB/OB MICE; MESSENGER-RNA; SECRETION; RAT; SENSITIVITY; ACTIVATION; RELEASE; ASSAY; CELLS;
Keywords:
insulin secretion; leptin; Lep(ob)/Lep(ob) mice; pancreatic islets;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Romsos, DR Michigan State Univ, Dept Food Sci & Human Nutr, E Lansing, MI 48824 USA Michigan State Univ E Lansing MI USA 48824 nsing, MI 48824 USA
Citazione:
J.W. Lee e D.R. Romsos, "Leptin-deficient mice commence hypersecreting insulin in response to acetylcholine between 1 and 2 weeks of age", EXP BIOL ME, 226(10), 2001, pp. 906-911

Abstract

Leptin-deficient Lep(ob)/Lep(ob) mice develop hyperinsulinemia early In life, before. they begin to overeat or develop Insulin resistance. PancreaticIslets from these young mice, do not yet hypersecrete insulin in response to glucose, but they hyperrespond to acetylcholine. Islets,from 4-day, and 1-, 2-, and 4-week-old mice were used In the present study to determine when leptin-deficient mice first hypersecrete Insulin in response to acetylcholine. This relative hypersecretion of Insulin from, Islets of leptin-deficient mice occurred between 1 and 2 weeks of age. The divergence in, Insulin secretion: occurred at this time because Islets from loan, leptin-sufficient mice became relatively less responsive to acetylcholine between 1 and 2 weeks of age, whereas Islets. from leptin-deficient mice maintained a high responsiveness to acetylcholine during development. Leptin addition to islets Isolated from 4-day, and 2-, and 4-week-old leptin-deficient mice rapidly(i.e., within 30 min), suppressed acetylcholine-induced Insulin secretion:at each: stage of development. In contrast, islets, from 4-day, and 2- and4-week-old leptin-sufficient mice became progressively less responsive to leptin. with development. Leptin targets, pancreatic Islets early In development to specifically constrain the overall capacity for acetylcholine-induced Insulin secretion, and to acutely modulate, this secretion.

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Documento generato il 02/04/20 alle ore 00:18:43