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Titolo:
Recent advances in membrane microdomains: Rafts, caveolae, and intracellular cholesterol trafficking
Autore:
Schroeder, F; Gallegos, AM; Atshaves, BP; Storey, SM; McIntosh, AL; Petrescu, AD; Huang, H; Starodub, O; Chao, H; Yang, HQ; Frolov, A; Kier, AB;
Indirizzi:
Texas A&M Univ, Dept Physiol & Pharmacol, TVMC, College Stn, TX 77843 USA Texas A&M Univ College Stn TX USA 77843 , TVMC, College Stn, TX 77843 USA Texas A&M Univ, Dept Pathobiol, TVMC, College Stn, TX 77843 USA Texas A&M Univ College Stn TX USA 77843 , TVMC, College Stn, TX 77843 USA
Titolo Testata:
EXPERIMENTAL BIOLOGY AND MEDICINE
fascicolo: 10, volume: 226, anno: 2001,
pagine: 873 - 890
SICI:
1535-3702(200111)226:10<873:RAIMMR>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
STEROL CARRIER PROTEIN-2; HIGH-DENSITY-LIPOPROTEIN; LIPID TRANSFER PROTEIN; ACID-BINDING-PROTEIN; L-CELL FIBROBLASTS; ACUTE REGULATORY PROTEIN; CHAIN FATTY-ACIDS; SYNAPTIC PLASMA-MEMBRANES; SCAVENGER RECEPTOR BI; GPI-ANCHORED PROTEINS;
Keywords:
membrane; domain; caveolae; rafts; cholesterol; fatty acid; sterol carrier protein;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
191
Recensione:
Indirizzi per estratti:
Indirizzo: Schroeder, F Texas A&M Univ, Dept Physiol & Pharmacol, TVMC, College Stn, TX 77843 USA Texas A&M Univ College Stn TX USA 77843 ge Stn, TX 77843 USA
Citazione:
F. Schroeder et al., "Recent advances in membrane microdomains: Rafts, caveolae, and intracellular cholesterol trafficking", EXP BIOL ME, 226(10), 2001, pp. 873-890

Abstract

Cellular cholesterol homeostasis is a balance of influx, catabolism and synthesis, and eff lux. Unlike vascular lipoprotein cholesterol transport, Intracellular cholesterol trafficking is only beginning to be resolved. Exogenous cholesterol and cholesterol ester enter cells via the low-density lipoprotein (LDL) receptor/ lysosomal and less so by nonvesicular, high-densitylipoprotein (HDL) receptor/caveolar pathways. However, the mechanism(s) whereby cholesterol enters the lysosomal membrane, translocates, and transfers out of the lysosome to the cell interior are unknown. Likewise, the stepswhereby cholesterol enters the cytofacial leaflet of the plasma membrane caveolae, rapidly translocates, leaves the exofacial leaflet, and transfers to extracellular HDL are unclear. Increasing evidence obtained with model and isolated cell membranes, transfected cells, genetic mutants, and gene-ablated mice suggests that proteins such as caveolin, sterol carrier protein-2 (SCP-2), Niemann-Pick C1 protein, steroidogenic acute regulatory protein (StAR), and other intracellular proteins mediate intracellular cholesterol transfer. While these proteins bind cholesterol and/or interact with cholesterol-rich membrane microdomains (e.g., caveolae, rafts, and annuli), theirrelative contributions to direct molecular versus vesicular cholesterol transfer remain to be resolved. The formation, regulation, and role of membrane microdomains in regulating cholesterol uptake/efflux and trafficking areunclear. Some cholesterol-binding proteins exert opposing effects on cellular cholesterol uptake/efflux, transfer of cholesterol out of the lysosomalmembrane, and/or intracellular cholesterol trafficking to select membranous organelles. Resolving these cholesterol pathways and the role of membranecholesterol microdomains is essential to our understanding not only of processes that affect cholesterol metabolism, but also of the abnormal regulation that may lead to disease (diabetes, obesity, atherosclerosis, neutral lipid storage, Niemann-Pick C, congenital lipoid adrenal hyperplasia, etc.).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 00:05:12