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Titolo:
Clinical features of a polymorphism of the beta(3)-adrenergic receptor gene in patients with type 2 diabetes mellitus - A study using a pin-point sequencing method
Autore:
Inukai, T; Tayama, K; Inukai, Y; Matsutoma, R; Takebayashi, K; Aso, Y; Takemura, Y;
Indirizzi:
Dokkyo Univ, Sch Med, Koshigaya Hosp, Dept Internal Med, Koshigaya 3438555, Japan Dokkyo Univ Koshigaya Japan 3438555 ternal Med, Koshigaya 3438555, Japan
Titolo Testata:
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
fascicolo: 7, volume: 109, anno: 2001,
pagine: 386 - 388
SICI:
0947-7349(2001)109:7<386:CFOAPO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUTATION; OBESITY;
Keywords:
beta(3)-adrenergic receptor gene; diabetes; preperitoneal fat; insulin resistance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Inukai, T Dokkyo Univ, Sch Med, Koshigaya Hosp, Dept Internal Med, Minami Koshigaya 2-1-50, Koshigaya 3438555, Japan Dokkyo Univ Minami Koshigaya 2-1-50 Koshigaya Japan 3438555 pan
Citazione:
T. Inukai et al., "Clinical features of a polymorphism of the beta(3)-adrenergic receptor gene in patients with type 2 diabetes mellitus - A study using a pin-point sequencing method", EXP CL E D, 109(7), 2001, pp. 386-388

Abstract

The human beta (3)-adrenergic receptor (beta (3)AR) is expressed specifically in adipose tissues, and its activation is activated in brown adipose tissues during thermogenesis and in white adipose tissues during lipolysis. We investigated the relationship between a polymorphism of the beta (3)AR gene and the clinical features of type 2 diabetes mellitus. Studies were conducted in 30 type 2 diabetic patients (15 males and 15 females). Analysis ofpolymorphisms of the beta (3)AR gene was performed by a pin-point sequencing method using the hair of the subjects. Preperitoneal (P-fat) and subcutaneous fat (S-fat) levels were determined by ultrasonography. We found a Trp(64)Arg allele of the beta (3)AR gene in the hair of 27% of all patients. The patients with this mutation showed a significantly younger onset-age of diabetes than those of tile wild type, The body mass index, serum GPT levels, fasting immunoreactive insulin (IRI) and daily urinary C-peptide reaction (CPR) in the mutation group were markedly higher than in the wild type group. The P-fat, serum cholesterol and leptin concentrations tended to be higher in the mutation group. Patients in the mutation group had a significantly higher prevalence of hypertension (80%) compared with those in the wildtype group (20%). Conclusions: The present results Suggest that the clinical features of diabetic patients with a missense mutation in the beta (3)ARgene are substantially distinct from those of tile wild type patients. These specific features include obesity, hyperinsulinemia, hypertension, and an increase in preperitoneal fat.

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Documento generato il 21/09/20 alle ore 16:06:16