Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
[H-1, N-15] NMR studies of the platination of phosphorothioate nucleotides- Monofunctional sulfur adducts versus macrochelation
Autore:
Kratochwil, NA; Parkinson, JA; Sacht, C; Murdoch, PD; Brown, T; Sadler, PJ;
Indirizzi:
Univ Edinburgh, Dept Chem, Edinburgh EH9 3JJ, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH9 3JJ Midlothian, Scotland Univ Southampton, Southampton SO16 7PX, Hants, England Univ Southampton Southampton Hants England SO16 7PX 6 7PX, Hants, England
Titolo Testata:
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
fascicolo: 11, , anno: 2001,
pagine: 2743 - 2746
SICI:
1434-1948(200111):11<2743:[NNSOT>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPLEMENTARY OLIGONUCLEOTIDES; VISIBLE-LIGHT; CISPLATIN; COMPLEXES; SEQUENCE; MONOPHOSPHATES; BINDING; LIGANDS;
Keywords:
chelates; drug research; nucleotides; sulfur; platinum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Sadler, PJ Univ Edinburgh, Dept Chem, W Mains Rd, Edinburgh EH9 3JJ, Midlothian, Scotland Univ Edinburgh W Mains Rd Edinburgh Midlothian Scotland EH93JJ
Citazione:
N.A. Kratochwil et al., "[H-1, N-15] NMR studies of the platination of phosphorothioate nucleotides- Monofunctional sulfur adducts versus macrochelation", EUR J INORG, (11), 2001, pp. 2743-2746

Abstract

cis-[PtI2((NH3)-N-15)(2)] reacts rapidly with guanosine-5'-O-(2-thiodiphosphate) (GDP-beta -S) to form a macrochelate in which Pt bridges the phosphorothioate S and guanine N7 atoms, Phosphorothioate(alpha -S)-containing self-complementary decamer oligonucleotides give rise to relatively long livedS-bound monofunctional adducts, the fate of which is sequence dependent.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 22:46:34