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Titolo:
The influence of tumour resection on angiostatin levels and tumour growth - an experimental study in tumour-bearing mice
Autore:
Li, TS; Kaneda, Y; Ueda, K; Hamano, K; Zempo, N; Esato, K;
Indirizzi:
Yamaguchi Univ, Dept Surg 1, Sch Med, Ube, Yamaguchi 7558505, Japan Yamaguchi Univ Ube Yamaguchi Japan 7558505 Ube, Yamaguchi 7558505, Japan
Titolo Testata:
EUROPEAN JOURNAL OF CANCER
fascicolo: 17, volume: 37, anno: 2001,
pagine: 2283 - 2288
SICI:
0959-8049(200111)37:17<2283:TIOTRO>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARENTERAL-NUTRITION; STIMULATING FACTOR; CELL-KINETICS; MURINE TUMORS; ANGIOGENESIS; SUPPRESSION; INHIBITOR; CARCINOMA; DORMANCY; REMOVAL;
Keywords:
angiostatin; tumour resection; inhibition; angiogenesis; apoptosis; proliferation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Li, TS Yamaguchi Univ, Dept Surg 1, Sch Med, 1-1-1 Minami Kogushi, Ube, Yamaguchi7558505, Japan Yamaguchi Univ 1-1-1 Minami Kogushi Ube Yamaguchi Japan 7558505 pan
Citazione:
T.S. Li et al., "The influence of tumour resection on angiostatin levels and tumour growth - an experimental study in tumour-bearing mice", EUR J CANC, 37(17), 2001, pp. 2283-2288

Abstract

The phenomenon of primary neoplasms inhibiting the growth of their metastatic lesions is thought to be related to endogenous angiogenesis inhibitors. The aim of this experiment was to investigate the influence of tumour resection on angiostatin levels and tumour growth using a tumour-bearing mouse model. A primary Lewis lung cancer tumour model was established in C57BL/6 mice and these mice were divided into two groups 10 days after the tumour cells were inoculated. In the surgical resection group (S group) the tumour was resected, but in the control group (C group) a sham operation was performed. The level of angiostatin in the sera was analysed 5 days after the operation by western blotting. To observe tumour growth, four Lewis lung cancer models were established in these mice from both the S and C groups. An immunohistochemical analysis of the tumour tissues was conducted to estimatethe proliferation and apoptotic rates of the tumour cells, as well as the amount of neoangiogenesis in the tumours. Angiostatin was observed in the tumour-bearing mice, but disappeared within 5 days after the tumour had beenresected. Increased tumour growth was observed in all of the tumour modelsin the S group compared with the C group and the differences were significant. A significantly higher intratumour vessel density and proliferation cell index, but a significantly lower apoptotic index were also found in the S group compared with the C group. These findings demonstrated that angiostatin was generated directly from the tumour tissue. Furthermore, tumour resection accelerates the growth of other tumours and this is probably relatedto multiple factors including increased neoangiogenesis, increased tumour cell proliferation, and decreased apoptosis. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 12:31:06