Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Arrhythmia substrate and management in hypertrophic cardiomyopathy: from molecules to implantable cardioverter-defibrillators
Autore:
Janse, MJ; De Bakker, JMT;
Indirizzi:
Univ Amsterdam, Acad Med Ctr J127, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands Univ Utrecht, Heart Lung Inst, NL-3508 TC Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3508 TC 3508 TC Utrecht, Netherlands
Titolo Testata:
EUROPEAN HEART JOURNAL SUPPLEMENTS
fascicolo: L, volume: 3, anno: 2001,
pagine: L15 - L20
SICI:
1520-765X(200110)3:L<L15:ASAMIH>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIAC TROPONIN-T; SUDDEN-DEATH; VENTRICULAR-TACHYCARDIA; IMPROVED SURVIVAL; HEART-FAILURE; MUTATIONS; POPULATION; CONDUCTION; RISK; ABNORMALITIES;
Keywords:
triggered activity; delayed afterdepolarizations; fibrosis; abnormal gap junction distribution; re-entry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Janse, MJ Univ Amsterdam, Acad Med Ctr J127, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Meibergdreef 9 Amsterdam Netherlands NL-1105 AZ
Citazione:
M.J. Janse e J.M.T. De Bakker, "Arrhythmia substrate and management in hypertrophic cardiomyopathy: from molecules to implantable cardioverter-defibrillators", EUR H J SUP, 3(L), 2001, pp. L15-L20

Abstract

Ventricular arrhythmias and Sudden death are among the characteristics of hypertrophic cardiomyopathy. Experience with the implantable cardioverter-defibrillator has shown that sudden death is caused by ventricular tachycardia or fibrillation. Several triggers for sudden death have been proposed arrhythmias: ischaemia; and abnormal response to exercise. The substrates forarrhythmias includes hypertrophy itself, predisposing to triggered activity based on delayed afterdepolarizations fibrosis, leading to abnormal, zig-zag conduction and fractionated extracellular electrograms, and abnormal distribution of gap junctions, especially in areas of myofibrillar disarray, which also may lead to conduction abnormalities. The latter two factors predispose to re-entry. (C) 2001 The European Society of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:22:06