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Titolo:
Genomic circuits and the integrative biology of cardiomyopathies
Autore:
Chien, KR;
Indirizzi:
Univ Calif San Diego, Inst Mol Med, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 ol Med, La Jolla, CA 92093 USA
Titolo Testata:
EUROPEAN HEART JOURNAL SUPPLEMENTS
fascicolo: L, volume: 3, anno: 2001,
pagine: L3 - L9
SICI:
1520-765X(200110)3:L<L3:GCATIB>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART-FAILURE; DILATED CARDIOMYOPATHY; MUSCULAR-DYSTROPHY; CARDIAC MYOCYTES; GENE; MUTATIONS; MUSCLE; STRESS; REQUIREMENT; DISRUPTION;
Keywords:
networks; conserved; cardiac-specific genes; genomic databases; integrated genomic circuits;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Chien, KR Univ Calif San Diego, Sch Med, Salk Program Mol Med, 0613-C, La Jolla, CA 92093 USA Univ Calif San Diego 0613-C La Jolla CA USA 92093 , CA 92093 USA
Citazione:
K.R. Chien, "Genomic circuits and the integrative biology of cardiomyopathies", EUR H J SUP, 3(L), 2001, pp. L3-L9

Abstract

A growing body of clinical and experimental evidence has led to the identification of nodal points in the pathways that drive the onset and progression of human cardiomyopathies. Studies of familial forms of human cardiomyopathy have documented that there are links between sarcomeric and cytoskeletal components, and onset of hypertrophic and dilated cardiomyopathy, respectively. Studies of gene-targeted mice suggest that pathways that guide biomechanical signalling, myocyte survival, cardiac calcium cycling and the electrophysiological function of conduction system lineages may play critical roles in the onset of distinct phenotypes that arise in human forms of cardiomyopathy. The present brief review highlights a few of these recent advances and provides a perspective for future clinical and experimental studies. (C) 2001 The European Society of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 11:49:45