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Titolo:
A polymorphism in the endothelin-A receptor gene predicts survival in patients with idiopathic dilated cardiomyopathy
Autore:
Herrmann, SM; Schmidt-Petersen, K; Pfeifer, J; Perrot, A; Bit-Avragim, N; Eichhorn, C; Dietz, R; Kreutz, R; Paul, M; Osterziel, KJ;
Indirizzi:
Free Univ Berlin, Benjamin Franklin Med Ctr, Inst Clin Pharmacol & Toxicol, Dept Clin Pharmacol, D-12200 Berlin, Germany Free Univ Berlin Berlin Germany D-12200 armacol, D-12200 Berlin, Germany Humboldt Univ, Max Delbruck Ctr Mol Med, Franz Volhard Klin, Berlin, Germany Humboldt Univ Berlin Germany l Med, Franz Volhard Klin, Berlin, Germany
Titolo Testata:
EUROPEAN HEART JOURNAL
fascicolo: 20, volume: 22, anno: 2001,
pagine: 1948 - 1953
SICI:
0195-668X(200110)22:20<1948:APITER>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC HEART-FAILURE; MYOCARDIAL-INFARCTION; CONVERTING ENZYME; CARDIAC-FUNCTION; BLOOD-PRESSURE; ANTAGONIST; FREQUENCY; VASOCONSTRICTION; CLASSIFICATION; INVOLVEMENT;
Keywords:
endothelin-A receptor; genetic polymorphism; dilative cardiomyopathy; survival;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Herrmann, SM Free Univ Berlin, Benjamin Franklin Med Ctr, Inst Clin Pharmacol & Toxicol, Dept Clin Pharmacol, Hindenburgdamm 30, D-12200 Berlin, Germany Free Univ Berlin Hindenburgdamm 30 Berlin Germany D-12200 ny
Citazione:
S.M. Herrmann et al., "A polymorphism in the endothelin-A receptor gene predicts survival in patients with idiopathic dilated cardiomyopathy", EUR HEART J, 22(20), 2001, pp. 1948-1953

Abstract

Aims The endothelin system plays a role in the complex pathophysiology of idiopathic dilated cardiomyopathy. We investigated whether genetic polymorphisms of the endothelin system might be associated with dilated cardiomyopathy-related cardiac phenotypes and differences in disease outcome. Methods One hundred and twenty-five unrelated dilated cardiomyopathy patients of a well characterized dilated cardiomyopathy cohort were genotyped for six common polymorphisms of the endothelin-1, endothelin-A (ETA) and endothelin-B (ETB) receptor genes using hybridization with allele-specific oligonucleotides. Results The H323H (C/T) polymorphism in exon 6 of the ETA receptor gene was significantly associated with a shorter survival time after diagnosis. The odds ratio for carriers of the less frequent ETA T allele to die within 2years after diagnosis was 5-5 (95% confidence interval, 1.4 to 21.0, P=0.013) compared to non-carriers. Kaplan-Meier analysis revealed a significantly different survival time for T allele carriers as compared to non-carriersas tested by logrank (P=0.0196), Breslow (P=0.0195), and Tarone tests (P=0.020). The influence of the ETA H323H polymorphism on survival remained significant when known predictors of prognosis such as left ventricular ejection fraction, left ventricular end-diastolic diameter, age and NYHA functional classification were entered in a Cox proportional hazards analysis. In this model, end-diastolic diameter showed a trend to influence survival (P=0.07) but only the ETA H323H polymorphism (P=0.0029) was a significant independent predictor of survival. Conclusions Our results suggest that genetic variation in the ETA receptorpredicts survival in dilated cardiomyopathy patients. which might have important consequences for the identification of high-risk individuals. (C) 2001 The European Society of Cardiology.

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Documento generato il 04/04/20 alle ore 02:32:43