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Titolo:
Animal models of fulminant hepatic failure: need to test liver support devices
Autore:
Filipponi, F; Mosca, F;
Indirizzi:
Univ Pisa, Dept Oncol Transplantat & Adv Technol Med, I-56100 Pisa, Italy Univ Pisa Pisa Italy I-56100 ntat & Adv Technol Med, I-56100 Pisa, Italy
Titolo Testata:
DIGESTIVE AND LIVER DISEASE
fascicolo: 7, volume: 33, anno: 2001,
pagine: 607 - 613
SICI:
1590-8658(200110)33:7<607:AMOFHF>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOTAL HEPATECTOMY; INTRACRANIAL HYPERTENSION; BIOARTIFICIAL LIVER; ACETAMINOPHEN; TRANSPLANTATION; PIG; NECROSIS; HEPATOTOXICITY; DISEASE; RABBIT;
Keywords:
animal models; artificial liver; fulminant hepatic failure; liver transplantation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Filipponi, F Osped Cisanello, Sez Trapiantol Epat, Via Paradisa 2, I-56100Pisa, Italy Osped Cisanello Via Paradisa 2 Pisa Italy I-56100 isa, Italy
Citazione:
F. Filipponi e F. Mosca, "Animal models of fulminant hepatic failure: need to test liver support devices", DIG LIVER D, 33(7), 2001, pp. 607-613

Abstract

Fulminant hepatic failure is one of the most dramatic entities in clinicalmedicine, but experimental studies of its pathogenesis, evolution and treatment have, so far, been limited by the lack of satisfactory animal models for testing new supportive treatment options. The variable aetiology, complex pathogenetic mechanisms and inconstant clinical evolution of human fulminant hepatic failure make it particularly difficult to establish an "ideal fulminant hepatic failure animal model" suitable for all studies: it is no longer mandatory to develop one single model serving all possible scientific needs, but the use of a specific model for a specific issue is more advisable, The currently available animal models of fulminant hepatic failure are the hepatotoxic, surgical and combined hepatotoxic and surgical models. From a general point of view, surgical models may be particularly appropriate for studying the consequences of hepatic necrosis on cerebral oedema. Theanhepatic model is very useful for validating new supportive measures to bridge the period between the onset of fulminant hepatic failure and the time at which a suitable organ becomes available and, despite the many difficulties involved in their development, hepatotoxic models may still be usefulfor mimicking an acetaminophen overdose. The efficacy and reproducibility of a liver support system can be demonstrated by means of preclinical experimental models that mimic the specific application required in humans as closely as possible.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 19:02:32