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Titolo:
Clinical pharmacology and safety profile of esomeprazole, the first enantiomerically pure proton pump inhibitor
Autore:
Tonini, M; Vigneri, S; Savarino, V; Scarpignato, C;
Indirizzi:
Univ Pavia, Dipartimento Sci Fisiol Farmacol, I-27100 Pavia, Italy Univ Pavia Pavia Italy I-27100 Sci Fisiol Farmacol, I-27100 Pavia, Italy Univ Palermo, Dept Internal Med, Div Gastroenterol, I-90133 Palermo, ItalyUniv Palermo Palermo Italy I-90133 Gastroenterol, I-90133 Palermo, Italy Univ Genoa, Dept Internal Med, Div Gastroenterol, I-16126 Genoa, Italy Univ Genoa Genoa Italy I-16126 , Div Gastroenterol, I-16126 Genoa, Italy Univ Parma, Dept Internal Med, Lab Clin Pharmacol, I-43100 Parma, Italy Univ Parma Parma Italy I-43100 Lab Clin Pharmacol, I-43100 Parma, Italy
Titolo Testata:
DIGESTIVE AND LIVER DISEASE
fascicolo: 7, volume: 33, anno: 2001,
pagine: 600 - 606
SICI:
1590-8658(200110)33:7<600:CPASPO>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTROESOPHAGEAL REFLUX DISEASE; CONTROLLED TRIAL; ACID PUMP; OMEPRAZOLE; METABOLISM; LANSOPRAZOLE; RABEPRAZOLE; MANAGEMENT; DISORDERS; EFFICACY;
Keywords:
acid-related disorders; clinical pharmacology; esomeprazole; proton pump inhibitors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Tonini, M Univ Pavia, Dipartimento Sci Fisiol Farmacol, Piazza Botta 10, I-27100 Pavia, Italy Univ Pavia Piazza Botta 10 Pavia Italy I-27100 100 Pavia, Italy
Citazione:
M. Tonini et al., "Clinical pharmacology and safety profile of esomeprazole, the first enantiomerically pure proton pump inhibitor", DIG LIVER D, 33(7), 2001, pp. 600-606

Abstract

Awareness of important differences in the pharmacological profile of individual optical isomers of chiral drugs led to the development of esomeprazole, the S-isomer of omeprazole, a new pharmacological entity designed to improve the clinical outcome of available proton pump inhibitors in the management of acid-related disorders. The superior acid control achieved by esomeprazole is mainly due to an advantageous metabolism compared with racemate omeprazole, leading to improved bioavailability and to enhanced delivery ofthe drug to the gastric proton pump.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 22:19:49