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Titolo:
Factor V Leiden and prothrombin gene mutation in inflammatory bowel disease in a Mediterranean area
Autore:
Turri, D; Rosselli, M; Simioni, P; Tormene, D; Grimaudo, S; Martorana, G; Siracusa, S; Mariani, G; Cottone, M;
Indirizzi:
Univ Palermo, Chair Hematol, I-90133 Palermo, Italy Univ Palermo PalermoItaly I-90133 Chair Hematol, I-90133 Palermo, Italy Osped V Cervello, Clin Med R, Palermo, Italy Osped V Cervello Palermo Italy d V Cervello, Clin Med R, Palermo, Italy Univ Padua, Inst Med, I-35100 Padua, Italy Univ Padua Padua Italy I-35100 niv Padua, Inst Med, I-35100 Padua, Italy
Titolo Testata:
DIGESTIVE AND LIVER DISEASE
fascicolo: 7, volume: 33, anno: 2001,
pagine: 559 - 562
SICI:
1590-8658(200110)33:7<559:FVLAPG>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENOUS THROMBOSIS; RISK; PREVALENCE;
Keywords:
factor V Leiden; inflammatory bowel disease; prothrombin gene;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Cottone, M Osped V Cervello, Clin Med R, Palermo, Italy Osped V Cervello Palermo Italy o, Clin Med R, Palermo, Italy
Citazione:
D. Turri et al., "Factor V Leiden and prothrombin gene mutation in inflammatory bowel disease in a Mediterranean area", DIG LIVER D, 33(7), 2001, pp. 559-562

Abstract

Background. Thromboembolism has been reported to be associated with inflammatory bowel disease. Aim. To evaluate the association of factor V Leiden and prothrombin gene mutation with inflammatory bowel disease in a population of patients with thromboembolic events and inflammatory bowel disease and in a control population of patients with inflammatory bowel disease without thromboembolic events. Patients and methods. A series of 18 patients with inflammatory bowel disease and a history of arterial or venous thrombosis and 45 patients with inflammatory bowel disease without thromboembolic events were evaluated for the presence of factor V Leiden and prothrombin gene mutation. Frequency of gene mutation was compared with its occurrence in 100 healthy controls. Results. One patient with inflammatory bowel disease without thromboembolic events was heterozygous for factor V Leiden mutation. whereas no patient with a thromboembolic event had factor V Leiden mutation. No patients (either cases or controls) had prothrombin gene mutation, In the healthy population the frequency of factor V Leiden and prothrombin mutation was 5% and 2%, respectively. Conclusions. Data emerging from the present study do not support any role of factor V Leiden and prothrombin gene mutation as the cause of thromboembolism in inflammatory bowel disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 10:52:44